Exploration for the value of CT-3D imaging technique in assessing SAD of asthma
10.3969/j.issn.1672-8270.2025.04.010
- VernacularTitle:CT三维成像技术在儿童哮喘小气道病变评估中的价值研究
- Author:
Yanmeng CHEN
1
;
Kaizhen PENG
;
Jingwei SUN
Author Information
1. 南京医科大学第一附属医院儿科 南京 210000
- Publication Type:Journal Article
- Keywords:
Small airway disease(SAD);
Multi-slice spiral computed tomography(CT);
Asthma;
Child
- From:
China Medical Equipment
2025;22(4):48-52
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the clinical value of computed tomography-three-dimensional(CT-3D)imaging technique in assessing small airway disease(SAD)in children with asthma.Methods:A total of 104 pediatric patients with suspected SAD,who admitted to our hospital from September 2021 to August 2024,were selected,and they were divided into lesion group(48 cases,with obstruction in small airway)and control group(56 cases,lung function without abnormality)according to the results of test for pulmonary function.Both two groups underwent test for lung function and respiratory biphasic CT scan,and the manifestations of high resolution CT(HRCT)image were observed.The correlation between the SAD and the relative indicators of determining ventilation function of lung,which included maximum mid-expiratory flow(MMEF25-75%),forced expiratory flow at 75%vital capacity(FEF75%),forced expiratory flow at 50%vital capacity(FEF 50%),forced expiratory flow at 25%vital capacity(FEF25%)and forced expiratory volume at the first second(FEV1),was analyzed.Results:The MMEF25-75%,FEF75%,FEF50%,FEF25%and FEV1 in the lesion group were significantly lower than those of the control group(t=8.735,12.757,9.724,13.928,10.303,P＜0.05).The incidences of bronchial wall thickening,air retention,Mosaic sign and bronchiole obstruction of HRCT signs of the lesion group were significantly higher than those of the control group(x2=10.715,6.119,6.330,6.587,P＜0.05).Bronchial wall thickening significantly correlated with MMEF25-75%,FEF75%,FEF50%,FEF25%and FEV1(r=-0.360,-0.379,-0.374,-0.367,-0.268,P＜0.001),respectively,and the correlation between it and FEF75%was extremely strong.Air retention significantly correlated with FEF75%and FEV1(r=-0.249,-0.240,P＜0.05),respectively.The Mosaic sign significantly correlated with MMEF25-75%,FEF75%and FEV1(r=-0.236,-0.245,0.257,P＜0.05),respectively.Bronchial obstruction significantly correlated with MMEF25-75%,FEF75%,FEF50%and FEV1(r=-0.248,-0.271,-0.253,-0.275,P＜0.05),respectively.The incidence of asthma in the lesion group was significantly higher than that in the control group(x2=36.783,P＜0.05).Conclusion:The incidence of bronchiolar wall thickening,air retention,Mosaic sign and bronchiolar obstruction of HRCT signs significantly increase in SAD children.They highly correlated with the indicators of ventilation function of lung,especially FEF75%and FEV1,which can reflect the function of small airway at a certain extent.They have great value for identifying early SAD.The application of CT-3D imaging technique in SAD children has a certain of predictive value for the occurrence of asthma.
