Association between glutamyl transpeptidase and risk of new onset diabetes in middle aged and elderly population
10.3969/j.issn.1006-6187.2025.01.005
- VernacularTitle:谷氨酰转肽酶与中老年人群新发糖尿病风险相关性的研究
- Author:
Jianchang QU
1
;
Jingtao DOU
;
Anping WANG
Author Information
1. 100017 北京,解放军第三〇五医院内分泌科
- Publication Type:Journal Article
- Keywords:
Glutamyl transpeptidase;
Diabetes mellitus;
Risk factors
- From:
Chinese Journal of Diabetes
2025;33(1):23-27
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the association between glutamyl transpeptidase(GGT)and the risk of newly diagnosed diabetes mellitus(DM)in middle aged and elderly population.Methods A retrospective cohort study was conducted,with baseline data sourced from the Beijing sub center population of the"Risk Evaluation of Cancersin Chinese Diabetic Individuals:A Longitudinal Study(REACTION)".A total of 6425 non DM individuals were enrolled in this study.All the participantswere divided into four groups according to GGT levels:G1(GGT<14.6 U/L,n=1601),G2(14.6 U/L≤GGT<19.3 U/L,n=1601),G3(19.3 U/L≤GGT<27.3 U/L,n=1613)and G4(GGT≥27.3 U/L,n=1610)group.They were followed up for 3.2 years.Results During follow-up,556 new DM cases were found,with a cumulative incidence rate of 8.7%.Logistic regression analysis showed that GGT was an independent risk factor for new DM in the non DM population,the risk of new DM in the G3,G4 groups was 1.730 times(95%CI 1.321～2.265,P<0.001)and 1.960 times(95%CI 1.493～2.587,P<0.001)of G1 group,respectively.GGT is also an independent risk factor for new DM in the impaired glucose regulation(IGR),the risk of new DM was 1.530 times higher in the G3 group(95%CI 1.123～2.094,P=0.008),and 1.750 times higher in the G4 group(95%CI 1.271～2.415,P=0.001)than in the G1 group.GGT is not an independent risk factor for new DM in participants with normal glucose tolerance(P>0.05).Conclusions GGT is a risk factor for new onset DM in IGR population.
