Research Progress of Traditional Chinese Medicine Intervention on Sepsis Based on MAPK Signaling Pathway
- VernacularTitle:基于MAPK信号通路的中医药干预脓毒症的研究进展
- Author:
Jinchan PENG
1
;
Sheng XIE
;
Guangyao WANG
;
Zhu LIU
;
Nan CHEN
;
Chengning YANG
;
Jing YAN
;
Yaoxuan ZENG
;
Jincheng QIAN
;
Liqun LI
Author Information
- Publication Type:Journal Article
- Keywords: Sepsis; MAPK signaling pathway; Traditional Chinese medicine; Inflammatory factor; Research progress
- From: World Science and Technology-Modernization of Traditional Chinese Medicine 2024;26(11):3006-3015
- CountryChina
- Language:Chinese
- Abstract: Sepsis is a life-threatening Organ Dysfunction disease caused by the dysregulated response of the body to infection.It is characterized by fever,chills,shortness of breath,altered consciousness,and even severe complications such as Multiple Organ Dysfunction Syndrome(MODS).The morbidity and mortality of this disease are high year after year,and there are problems such as large consumption of medical resources and poor prognosis,which seriously affect the quality of life and economic burden of patients.Therefore,it is important to explore new treatments with high efficiency,safety and low cost.The disease pathogenesis is complex,including inflammation imbalance is the main pathogenesis of sepsis.Mitogen-Activated Protein Kinases(MAPK)signaling pathway is a signaling pathway activated by environmental factors or inflammatory factors,which mediates proliferation,differentiation,inflammatory response and apoptosis,and plays a key role in the occurrence and development of sepsis.At present,antibiotics,fluid resuscitation and mechanical ventilation are the main methods for clinical treatment of sepsis.Although they can curb the progress of some diseases,some treatment effects are not good.A large amount of literature has confirmed that Chinese medicine intervention in sepsis has significant advantages,its through many channels,regulation and control of multiple targets,MAPK signaling pathways,inhibit inflammation,strengthening immune defense and effective in the treatment of sepsis,sepsis is current research hotspot.However,there is still a lack of systematic reviews on the regulation of MAPK signaling pathway by traditional Chinese medicine in the treatment of sepsis.Therefore,based on the retrieval database sepsis related literature at home and abroad in recent years,a systemic summary of MAPK signal pathway and sepsis relations and the role of traditional Chinese medicine in them,will be new drugs for the treatment of sepsis and development provides new theoretical support.
