Visualization analysis of knowledge map and trends in glymphatic system research
- VernacularTitle:胶质淋巴系统研究的知识图谱与趋势可视化分析
- Author:
Xingyi MA
1
;
Huijing LI
;
Juan LI
;
Dongling ZHONG
;
Yuan ZHANG
;
Hong TANG
;
Yuxi LI
;
Rongjiang JIN
Author Information
- Publication Type:Journal Article
- Keywords: glymphatic system; current research status; research hotspots; development trends; visualization map; CiteSpace; VOSviewer; R language
- From: Chinese Journal of Tissue Engineering Research 2025;29(23):5051-5060
- CountryChina
- Language:Chinese
- Abstract: BACKGROUND:The clearance pathway of metabolic waste in the brain is crucial for maintaining neural homeostasis.The accumulation of metabolic waste disrupts this equilibrium,representing a common pathological feature of many central nervous system diseases.In recent years,research focusing on the glymphatic system has emerged as a hotspot in the nervous system field.OBJECTIVE:To construct a knowledge map of glymphatic system research,visually analyze the current state of research,main hotspots,and future development trends within this area.METHODS:Utilizing CiteSpace,VOSviewer,and the Bibliometrix package in the R language environment,this study conducted an in-depth visual analysis of glymphatic system-related literature from the Web of Science Core Collection database,spanning from January 2012 to March 2024.This analysis included authors,institutions,countries,journals,keywords,and co-citation frequencies.RESULTS AND CONCLUSION:A total of 687 related articles were included in this study.The number of publications in this field increased year by year,showing an explosive growth trend in the past three years.The countries,institutions,and authors with the largest number of publications in this research field were the United States,University of Rochester,and Professor Maiken Nedergaard.The journal with the highest number of publications was JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM.The high-frequent and high-central keywords mainly focused on the mechanism such as cerebrospinal fluid hydrodynamics,neurological diseases such as Alzheimer's disease,and imaging techniques such as diffusion tensor imaging.The literature with the highest co-citation frequency was a classic review of the glymphatic system.The above results show that the research of glymphatic system is an emerging and active field,which has attracted wide attention at home and abroad and gradually expand from theoretical research to clinical practice.
