Efficacy of intracoronary injection of adenosine and sodium nitroprusside before PCI in patients with attenuated plaques
10.12007/j.issn.0258-4646.2025.09.004
- VernacularTitle:衰减斑块患者PCI术前冠状动脉内注射腺苷及硝普钠的疗效分析
- Author:
Shuo WANG
1
;
Liu LI
;
Zhichao GAO
;
Hong GENG
;
Lei XU
;
Rubing WU
Author Information
1. 石家庄市人民医院心内科,石家庄 050031
- Publication Type:Journal Article
- Keywords:
attenuated plaque;
adenosine;
sodium nitroprusside;
percutaneous coronary intervention;
no-reflow
- From:
Journal of China Medical University
2025;54(9):786-790
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the efficacy of preprocedural intracoronary injections of adenosine and sodium nitroprusside in patients with intravascular ultrasound-attenuated plaques(AP).Methods In total,200 patients with AP detected using intravascular ultrasound(IVUS)at Shijiazhuang People's Hospital from January 1,2022,to January 1,2024,were selected and randomly divided into conventional treatment and pretreatment groups,with 100 patients in each group.The conventional treatment group underwent standard percutaneous coronary intervention(PCI)procedures,whereas the pretreatment group underwent intracoronary injection of sodium nitro-prusside and adenosine through a guiding catheter prior to PCI.The observation parameters included intraoperative no-reflow(NR)inci-dence,post-PCI TIMI myocardial perfusion frame count(TMPFC),perioperative myocardial infarction(PMN),and 6-month major adverse cardiac and cerebrovascular events(MACCE).Results The pretreatment group exhibited a significantly lower intraoperative NR inci-dence,reduced postoperative TMPFC,and attenuated PMN severity than the conventional treatment group(P＜0.05).Conclusion Pre-procedural intracoronary administration of adenosine and sodium nitroprusside through a guiding catheter can effectively reduce PCI-re-lated NR occurrence,improve post-PCI TMPFC,and mitigate PMN in patients with AP,although no significant improvement in MACCE incidence can be observed at the 6-month follow-up.
