Relationship between biological mechanism of selenium and selenium nanoparticles and common oral diseases
- VernacularTitle:硒及硒纳米颗粒生物学机制与口腔常见疾病的关系
- Author:
Luyao PENG
1
;
Yu GU
Author Information
- Publication Type:Journal Article
- Keywords: selenium; selenium nanoparticle; oral neoplasms; caries; pupal and periapical disease; dental implant
- From: Chinese Journal of Tissue Engineering Research 2025;29(22):4813-4822
- CountryChina
- Language:Chinese
- Abstract: BACKGROUND:As an essential trace non-metallic element in the human body,selenium has been widely used in the biomedical field due to its potential anti-inflammatory,antioxidant,antibacterial,immunomodulatory,anti-tumor and other biological activities.OBJECTIVE:To summarize the anti-inflammatory,antioxidant,antibacterial,immunomodulatory,and anti-tumor effects and mechanisms of selenium and selenium nanoparticles,and research progress in the field of stomatology.METHODS:Literature searches were conducted on PubMed,CNKI,and WanFang databases using Chinese and English search terms"selenium,selenium nanoparticles,oral neoplasms,caries,dental pupal disease,periapical disease,dental implant."The searched relevant articles were published from January 2000 to February 2024.After thoroughly analyzing and reading,74 articles were ultimately included for review.RESULTS AND CONCLUSION:(1)The biological characteristics of selenium are mainly achieved through the synthesis of selenoproteins,with antioxidant mechanisms as the core,regulating various cytokines and mediating related signaling pathways,thereby producing antibacterial,immune regulatory,and antitumor effects.(2)In addition to being used for early diagnosis,treatment,and postoperative judgment in oral cancer,caries,pulp and periapical diseases,selenium can also be used as a new type of material in the oral field.For example,it can be used to develop new dental sealants or root canal system disinfectants.Besides,it has a promoting effect on optimizing the performance of oral implant materials.(3)One of the most significant factors that affect the application of selenium in the field of biomedicine is biological safety.Only by selecting the appropriate dosage and form can it maximize its effects.Selenium has also shown great potential for application as well as broad development space in oral materials science.
