Effects of self-assembling peptide hydrogels on tumor treatment
- VernacularTitle:自组装短肽水凝胶治疗肿瘤的作用
- Author:
Huanhuan HE
1
;
Shijia TIAN
1
;
Luoying CHEN
1
;
Yanfei LIU
1
Author Information
- Publication Type:Journal Article
- Keywords: self-assembling peptide; hydrogel; sustained release; anti-tumor; tissue engineering
- From: Chinese Journal of Tissue Engineering Research 2025;29(22):4795-4803
- CountryChina
- Language:Chinese
- Abstract: BACKGROUND:Self-assembling peptide hydrogels exhibit excellent biocompatibility,controllable physicochemical properties,and release capabilities,offering extensive application potential in tissue engineering,drug delivery,and biosensing fields.OBJECTIVE:To summarize the research progress of self-assembling peptide hydrogel in cancer therapy in recent years.METHODS:Using the search terms"self-assembling peptides,hydrogel,sustained release,antitumor,tumor therapy"in Chinese and English,CNKI,PubMed,and Elsevier ScienceDirect databases were searched for relevant literature published from 2000 to 2024.Finally,81 articles were included in the review.RESULTS AND CONCLUSION:Self-assembling peptide hydrogels,as a novel biomaterial,can be used as a sustained-release drug carrier to load a variety of anti-tumor drugs,and immunosuppressants,targeting tumor sites,inducing tumor cell death,reducing drug dosage,and increasing drug accumulation in tumor sites,thereby reducing the probability of toxic side effects and multidrug resistance.Moreover,anti-tumor hydrogels with natural activity can directly kill tumor cells without relying on drugs,and can minimize the toxic side effects of anti-tumor drugs when used alone.
