Role of endoplasmic reticulum stress-autophagy in cerebral ischemia-reperfusion injury and the regulatory mechanism of traditional Chinese medicine
- VernacularTitle:脑缺血再灌注损伤中内质网应激-自噬的作用及中药调控机制
- Author:
Shuo ZHANG
1
;
Yinglin CUI
;
Panpan ZHOU
;
Yile LI
;
Lei WANG
;
Qianqian ZOU
Author Information
- Publication Type:Journal Article
- Keywords: endoplasmic reticulum stress; autophagy; cerebral ischemia-reperfusion injury; endoplasmic reticulum transmembrane protein; traditional Chinese medicine; signal pathway; engineered tissue construction
- From: Chinese Journal of Tissue Engineering Research 2025;29(20):4325-4332
- CountryChina
- Language:Chinese
- Abstract: BACKGROUND:Research has shown that endoplasmic reticulum stress-induced autophagy of neurons in the ischemic penumbra is a key link in cerebral ischemia-reperfusion injury.Autophagy mediated by the dissociation and activation of endoplasmic reticulum transmembrane proteins PERK,IRE1 α,ATF6,and GRP78/BIP plays an important role in neuronal outcomes.Traditional Chinese medicine can regulate endoplasmic reticulum stress-autophagy,reduce neuronal damage or death,and exert neuroprotective effects.OBJECTIVE:To explore the role of endoplasmic reticulum stress-autophagy in cerebral ischemia-reperfusion injury and the research progress in the regulatory mechanisms of traditional Chinese medicine.METHODS:A literature retrieval was conducted in CNKI and PubMed for relevant literature related to endoplasmic reticulum stress,autophagy,cerebral ischemia-reperfusion injury,and regulation by traditional Chinese Medicine published from January 2015 to May 2024.The search terms were"cerebral ischemia-reperfusion injury,ischemic stroke,brain injury,endoplasmic reticulum stress,autophagy,traditional Chinese medicine,compounds,signaling pathways,saponins,polyphenols,alkaloids"in Chinese and English,respectively.Any literature that is inconsistent with the research content,outdated,or duplicated was excluded.A total of 1197 relevant literature were retrieved,and 71 articles were ultimately included.RESULTS AND CONCLUSION:(1)Numerous studies have suggested that endoplasmic reticulum stress-autophagy is closely related with cerebral ischemia-reperfusion injury.(2)The active ingredients and compound formulas of traditional Chinese medicine monomers can regulate the expression of endoplasmic reticulum stress-autophagy related proteins,alleviate neuronal damage,and exert neuroprotective effects by regulating signal pathways such as PERK-eIF2α-ATF4,IRE1α-ASK1-JNK,and IRE1α-XBP.
