Pharmacokinetics Study of Galantamine Hydrobromide Following Intramuscular Administration in Rats
10.3870/j.issn.1004-0781.2025.08.003
- VernacularTitle:氢溴酸加兰他敏肌内注射在大鼠体内的药动学
- Author:
Yifei XIANG
1
;
Zhou ZHOU
;
Feng CHEN
;
Chuanrui XU
Author Information
1. 华中科技大学同济医学院药学院,武汉 430030
- Publication Type:Journal Article
- Keywords:
Galantamine hydrobromide;
Intramuscular injection;
Pharmacokinetics
- From:
Herald of Medicine
2025;44(8):1208-1214
- CountryChina
- Language:Chinese
-
Abstract:
Objective A high-performance liquid chromatography-tandem mass spectrometry(HPLC-MS/MS)method was developed to quantify galantamine concentrations in rat blood following intramuscular injection of galantamine hydrobromide and to investigate its pharmacokinetic profile.Methods Male and female SD rats were randomly divided into four groups,each with six rats(three males and three females).The single intramuscular injection group received a single intramuscular dose of hydrobromide galantamine at low,medium,and high doses(0.25,0.50 and 1.00 mg·kg1)in rats.The single intravenous injection group received a single intravenous dose of hydrobromide galantamine at 0.25 mg·kg-1.The multiple intramuscular injection group received hydrobromide galantamine at 0.50 mg·kg-1 via intramuscular injection once daily for 7 consecutive days with a 24-hour interval between doses.Pharmacokinetic parameters of galantamine were calculated for each treatment group.Results The peak concentrations(Cmax)of galantamine following a single intramuscular injection in the low,medium,and high-dose groups were(80.54±9.31),(168.25±47.92)and(314.33±46.51)ng·mL-1,respectively.The area under the concentration-time curve(AUC0-t)was(95.23±20.42),(182.21±36.63)and(380.43±70.71)ng·mL-1·h,respectively.Additionally,the accumulation index of galantamine in the multiple intramuscular dosing group was 1.09.Conclusion Intramuscular injection of galantamine hydrobromide has good bioavailability in rats.Meanwhile,when administered multiple times,the drug accumulates low in the body.The experimental results provide valuable reference for the clinical pharmacokinetic study and clinical application of hydrobromide galantamine injection.
