Survival Analysis of Biliary Tract Carcinoma Patients Receiving Integrated Traditional Chinese and Western Medicine Treatment:A Retrospective Cohort Study
10.3870/j.issn.1004-0781.2025.08.007
- VernacularTitle:中西医结合治疗胆道恶性肿瘤患者生存期的回顾性队列研究
- Author:
Junke XIAO
1
;
Chaofeng ZHOU
;
Sai WANG
;
Yu ZHANG
;
Jiaojiao GUO
;
Shangzhi YANG
;
Xiaoyan MU
;
Zhizhong GUO
Author Information
1. 河南中医药大学第二临床医学院,郑州 450002
- Publication Type:Journal Article
- Keywords:
Integrated traditional Chinese and Western medicine;
Biliary tract carcinoma;
Retrospective analysis;
Cohort study
- From:
Herald of Medicine
2025;44(8):1236-1241
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the impact of integrated traditional Chinese and Western medicine on the overall survival(OS)of patients with biliary tract carcinoma(BTC),and to analyze the related factors affecting the OS of patients with BTC,so as to provide accurate prognosis assessment for clinical diagnosis and treatment.Methods The medical records of 198 patients with BTC in Henan Provincial Hospital of Traditional Chinese Medicine from February 2018 to October 2023 were retrospectively analyzed.The Cox proportional hazards model was utilized to analyze the independent prognostic factors affecting the OS of BTC patients.Survival curves were constructed using the Kaplan-Meier method,and the Log-rank test was employed to compare median OS differences among various groups.Results A total of 116 patients with BTC were included.There were 59 cases(50.86％)in the Western medicine group,with a median OS of(14±2.77)months,and the 1-,2-and 3-year OS rates were 81.36％,61.02％and 46.11％,respectively.There were 57 cases(49.14％)in the integrated traditional Chinese and Western medicine group,with a median OS of(29±3.91)months,and the 1-,2-and 3-year OS rates were 82.32％,67.64％and 58.00％,respectively.There was a statistically significant difference in survival time between the two groups(P=0.038).Univariate analysis indicated that age,clinical stage,surgical treatment,chemotherapy,targeted therapy,local therapy and integrated traditional Chinese and Western medicine were significantly correlated with OS in BTC patients(all P＜0.05).Multivariate analysis revealed that age,clinical stage,surgical treatment,chemotherapy,targeted therapy,local therapy,and integrated traditional Chinese and Western medicine had significant effects on the OS of patients with BTC(all P＜0.05).Conclusion The median OS of the traditional Chinese and Western medicine groups was significantly longer than that of the Western medicine group,and the long-term OS rate of the patients was significantly better than that of the Western medicine group.Age,clinical stage,surgery,chemotherapy,targeted therapy,local therapy,and integrated traditional Chinese and Western medicine are independent prognostic factors affecting OS in patients with BTC.
