Advances in the Antitumor Pharmacological Mechanisms and Clinical Applications of Berberine
10.3870/j.issn.1004-0781.2025.08.006
- VernacularTitle:小檗碱抗肿瘤药理作用机制及临床应用进展
- Author:
Liangchun ZHOU
1
;
Jiaxin LYU
;
Dongyuan WANG
Author Information
1. 黄冈市中心医院药剂科,黄冈 438000
- Publication Type:Journal Article
- Keywords:
Berberine;
Tumor cell apoptosis;
Tumor cell immunotherapy;
Autophagy regulation;
Tumor metabolism;
Epigenetics
- From:
Herald of Medicine
2025;44(8):1229-1235
- CountryChina
- Language:Chinese
-
Abstract:
Berberine,an isoquinoline alkaloid,is abundant in plants such as Coptis and Phellodendri.It exhibits a wide range of pharmacological activities and has been effectively applied in the clinical treatment of metabolic diseases,infectious diseases,and inflammation.In recent years,berberine's anti-tumor effects have garnered significant attention.Research has demonstrated that berberine can inhibit tumor progression via multiple pathways,including inducing tumor cell apoptosis,regulating the tumor microbiome,arresting the cell cycle,inhibiting tumor angiogenesis,and enhancing the efficacy of tumor immunotherapy.Additionally,berberine can synergistically increase the sensitivity of chemotherapeutic drugs and reduce drug resistance by modulating key signaling pathways such as PI3K/Akt,MAPK,and NF-κB.The antioxidant and immunomodulatory properties of berberine further expand its potential for anti-tumor applications.Based on the findings from basic and clinical research,this review systematically summarizes the latest advances in berberine's anti-tumor mechanisms and clinical applications.It also discusses the challenges and potential solutions in the clinical translation of berberine for cancer therapy,providing a theoretical basis for its development as a novel anti-tumor drug.
