Immune metabolic interactions in uveitis:from metabolic checkpoints to treatment opportunities
10.13389/j.cnki.rao.2025.0141
- VernacularTitle:葡萄膜炎中的免疫代谢交互:从代谢检查点到治疗机遇
- Author:
Jiaxing LI
1
;
Dadong GUO
Author Information
1. 250014 山东济南市,山东中医药大学;250014 山东济南市,山东省血液中心
- Publication Type:Journal Article
- Keywords:
uveitis;
immunometabolic reprogramming;
metabolic checkpoint;
glycolysis;
oxidative phosphorylation;
fatty acid oxidation
- From:
Recent Advances in Ophthalmology
2025;45(10):820-824,840
- CountryChina
- Language:Chinese
-
Abstract:
Conventional uveitis treatments face challenges due to complications from broad-spectrum immunosuppres-sion and therapeutic resistance.Recent studies demonstrate that immunometabolic reprogramming drives disease progres-sion by modulating the metabolic plasticity of macrophages and T cells.The hypoxia inducible factor-1α(HIF-1α)/mamma-lian target of rapamycin complex 1(mTORC1)axis serves as a core metabolic checkpoint,whose dysregulation induces T helper cell 17(Th17)/regulatory T cell(Treg)imbalance.Mitochondrial dysfunction and epigenetic modifications further exacerbate disease chronicity.Although current therapeutics can suppress glycolysis or activate fatty acid oxidation to alle-viate inflammation,their efficacy is constrained by systemic toxicity and a 30％-40％resistance rate.Emerging targeted strategies(e.g.,nanocarrier-delivered mTOR inhibitors)show potential in intervening in metabolic vulnerabilities,yet en-counter bottlenecks including metabolic pathway heterogeneity.Future research should integrate single-cell multi-omics and develop ocular tissue-specific delivery systems to achieve individualized therapy based on metabolic checkpoints.
