Effects of hyperbaric oxygen on plasma endothelin and nitric oxide in patients with intrauterine growth retardation
10.3760/cma.j.issn.1009-6906.2020.01.022
- VernacularTitle:高压氧综合治疗对胎儿宫内发育迟缓患者的临床疗效及血浆内皮素、一氧化氮水平的影响
- Author:
Fang LIU
1
;
Guirong LYU
;
Yuan CAO
;
Hengyuan AN
Author Information
1. 450052 郑州，郑州大学第一附属医院妇产科
- Publication Type:Journal Article
- Keywords:
Hyperbaric oxygen;
Intrauterine growth retardation;
Plasma endothelin;
Nitric oxide
- From:
Chinese journal of nautical medicine and hyperbaric medicine
2020;27(1):83-86
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the effect of hyperbaric oxygen on plasma endothelin-1 (ET-1) and nitric oxide (NO) in patients with intrauterine growth retardation (IUGR) as well as the clinical efficacy.Methods:A total of 90 IUGR patients, treated in the First Affiliated Hospital of Zhengzhou University from January 2018 to May 2019, were selected and divided into the observation group and the control group according to the double-blind lottery method, with 45 patients in each group. The patients in the control group were only given routine treatment, while those in the observation group were treated with hyperbaric oxygen combined with the routine treatment as same as the control group. The therapeutic effects of the two groups were observed and recorded. The level of ET-1 was analyzed by enzyme linked immunosorbent assay, and the level of NO was tested by nitrate reductase colorimetry. The values of peak-to-diastolic ratio (S/D), resistant index (RI), and pulsation index (PI) at the end of umbilical artery vasoconstriction were detected by ultrasonic doppler umbilical cord blood flow analyzer. The levels of plasma TXB2 and 6-Keto-PGF1α were detected by radioimmunoassay.Results:After 3 weeks treatment, the total effective rate of the observation group (95.56%) was significantly higher than that of the control group (77.78%) ( χ2=7.168, P<0.05); compared with those before treatment, the levels of ET-1 and NO of both groups were significantly up-regulated; the ET-1 level of the observation group after treatment was significantly lower than that of the control group, while the NO level was significantly higher ( P<0.05). After treatment, the values of S/D, RI, and PI at the end of umbilical artery vasoconstriction of both the groups after treatment were all lower than those before treatment, especially the values of S/D, RI, and PI of the observation group after treatment were significantly lower than those of the control group ( P<0.05). Compared with those before treatment, the levels of patients′ plasma TXB2 and 6-keto-PGF1α of both the groups were significantly up-regulated; the level of patients′ plasma TXB2 of the observation group after treatment was significantly lower than that of the control group, while the level of 6-keto-PGF1α was significantly increased( P<0.05 or P<0.01). Conclusion:Hyperbaric oxygen could significantly improve the clinical effect on IUGR, and improve the fetal development. This treatment, therefore, is worthy of popularization and application in clinic.
