Progress of the Dll4-Notch signaling pathway in venous malformation
10.3760/cma.j.cn114453-20240805-00200
- VernacularTitle:Dll4-Notch信号通路在静脉畸形中的研究进展
- Author:
Gaozan ZHU
1
;
Junjie LIN
1
;
Junbo QIAO
1
Author Information
1. 郑州大学第三附属医院血管瘤外科 河南省血管瘤与血管畸形医学重点学科 河南省血管瘤与血管畸形医学重点实验室，郑州 450052
- Publication Type:Journal Article
- Keywords:
Receptors, Notch;
Vascular malformations;
Dll4;
Venous malformation;
Signal pathway
- From:
Chinese Journal of Plastic Surgery
2025;41(11):1207-1212
- CountryChina
- Language:Chinese
-
Abstract:
The Notch signaling pathway is a highly conserved cell signaling system. Delta-like ligand 4 (Dll4), the only Notch ligand specifically expressed in endothelial cells, plays a critical role in the formation of abnormal vascular lumens under physiological and pathological conditions. The Dll4-Notch signaling pathway is essential for the regulation of gene transcription. Venous malformation, the most common type of vascular malformation, is a vascular disease characterized by progressive destruction of multiple tissues and organs; however, the mechanisms underlying its invasive progression remain unclear. This article summarizes the biological characteristics of the Dll4-Notch signaling pathway and its roles in vasculogenesis, venous malformations, and other vascular anomalies. It has been found that the Dll4-Notch signaling pathway can influence venous lumen structure and may contribute to the persistent abnormal development of malformed veins, leading to local invasion. Current research on the Dll4-Notch signaling pathway in venous malformations is still in its preliminary stages, and further in-depth experimental studies are required to untangle the relationship between them.
