Pathological diagnosis of gastric adenocarcinoma with enteroblastic differentiation in endoscopic biopsies
10.13315/j.cnki.cjcep.2024.12.008
- VernacularTitle:伴肠母细胞分化胃腺癌内镜活检标本的病理诊断
- Author:
Fenglin ZANG
1
;
Yong WANG
;
Ruijun TANG
;
Xiyin WEI
;
Yuhong GUO
;
Yalei WANG
;
Tingting DING
Author Information
1. 天津医科大学肿瘤医院病理科/国家恶性肿瘤临床医学研究中心/天津市恶性肿瘤临床医学研究中心/天津市消化系统肿瘤重点实验室,天津 300060
- Publication Type:Journal Article
- Keywords:
gastric adenocarcinoma with enteroblastic differenti-ation;
early gastric cancer;
endoscopic biopsy;
pathological e-valuation
- From:
Chinese Journal of Clinical and Experimental Pathology
2024;40(12):1282-1287
- CountryChina
- Language:Chinese
-
Abstract:
Purpose To investigate the diagnosis and the clinicopathological characteristics of gastric adenocarcinoma with enteroblastic differentiation(GAED)in biopsy,and to provide data for the pathological evaluation of endoscopic resection of early gastric cancer.Methods 26 GAED biopsy specimens were collected,and the clinicopathological features were ana-lyzed by re-reading slides,immunohistochemistry and with paired radical surgery specimen.Results Serum AFP was de-tected in 16 patients before operation,and 11 patients(68.75％)were elevated.The initial diagnosis rate and follow-up rate of GAED in biopsy were 42.31％and 92.31％.Among the biopsy specimens,5 cases of GAED were accompanied by conventional gastric adenocarcinoma,and the positive rates of SALL4 and Glypican-3 were high(both 78.57％).The accom-panying cancers in the radical resection specimens include con-ventional gastric adenocarcinoma,hepatoid adenocarcinoma,and low adhesion adenocarcinoma,with the positive rate of SALL4(81.25％),Glypican-3(75％),and AFP(62.5％).GAED was more prone to deep invasion of the gastric wall and lymph node metastasis than conventional gastric adenocarcinoma.A-mong the 6 cases of early GAED,3 cases(50％)were lymph node-positive.Conclusion GAED is easy to be missed in biop-sy,and more attention should be paid to its tissue morphology and immunophenotype.GAED needs to be excluded in the histo-logical type of endoscopic curative resection of early gastric canc-er.
