MRI imaging characteristics of non-small cell lung cancer brain metastases with different epidermal growth factor receptor mutation types and PD-L1 expression
10.3969/j.issn.1002-1671.2025.09.011
- VernacularTitle:不同表皮生长因子受体突变类型及PD-L1表达非小细胞肺癌脑转移的MRI影像特征分析
- Author:
Bingxue MA
1
;
Xuhong MIN
;
Biao SONG
;
Shanghu WANG
;
Qilong SONG
;
Zhaohua WANG
;
Yunfu XU
;
Cheng CHEN
Author Information
1. 安徽省胸科医院医学影像科,安徽 合肥 230000
- Publication Type:Journal Article
- Keywords:
brain metastases;
epidermal growth factor receptor;
programmed cell death-ligand 1;
non-small cell lung cancer;
mag-netic resonance imaging
- From:
Journal of Practical Radiology
2025;41(9):1472-1476
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the MRI imaging characteristics of brain metastases in non-small cell lung cancer(NSCLC)with different epidermal growth factor receptor(EGFR)mutation types and programmed cell death-ligand 1(PD-L1)expression,and to provide imaging diagnostic support for patients who can't undergo genetic and immunohistochemical testing.Methods A retrospec-tive selection was performed in 88 patients diagnosed with brain metastases of NSCLC,all patients were divided into EGFR mutation group and wild group according to the results of genetic testing,and patients with EGFR mutation group were divided into EGFR mutation with PD-L1 expression positive group and EGFR mutation with PD-L1 expression negative group according to whether the expression of PD-L1 was≥1％.The clinical data and MR image characteristics of brain metastases were compared in EGFR mutation group and wild group,as well as in EGFR mutation with PD-L1 expression positive group and EGFR mutation with PD-L1 expres-sion negative group.Results There were statistically significant differences in smoking history and intracranial symptoms between EGFR mutation group and wild group(P＜0.05).The edema diameter,edema index and enhancement ratio of EGFR mutation group and wild group were(0.67±1.10)cm,0.39±0.54,0.32±0.17 and(1.57±2.04)cm,1.05±1.21,0.53±0.27,respectively,and the differences were statistically significant(P＜0.05).There were 43 cases and 23 cases in EGFR mutation group and wild group with ≥2 metastases,respectively,and the difference was statistically significant(P＜0.05).Compared with＞60 years old,there were 15 patients(75％)of EGFR mutation with PD-L1 expres-sion positive in≤60 years old(P＜0.05).Conclusion Compared with EGFR wild patients,patients with EGFR mutation have more brain metastases(≥2),milder enhancement,less peritumoral edema,and fewer intracranial symptoms at initial diagnosis,and patients with EGFR mutation aged≤60 years are more likely to have PD-L1 expression positive.
