Research advances in the role of NLRP3 inflammasome in the pathological mechanisms of multiple sclerosis:a review

VernacularTitle:基于NLRP3炎症小体的多发性硬化症病理机制研究进展
Author: Sihua HUANG ¹ ; Zheyi ZHOU ; Shuo WANG ; Junwei ZHONG ; Hongen YAN
Author Information

1. 广西中医药大学,南宁 530000;广西中医药大学第三附属医院(柳州市中医医院)神经内科,广西柳州 545002
Publication Type:Journal Article
Keywords: multiple sclerosis; NLRP3; medical treatments; experimental autoimmune encephalomyelitis
From: Chinese Journal of Comparative Medicine 2025;35(8):158-167
CountryChina
Language:Chinese
Abstract: Multiple sclerosis(MS)is a complex autoimmune disorder characterized by inflammatory demyelination in the central nervous system.Prominent symptoms include damage to myelin sheaths in the brain,optic nerve,and spinal cord,as well as axonal dysfunction;however,the exact causes and mechanisms of MS remain unclear.Genetic and environmental factors are thought to interact via autoimmune mechanisms,potentially triggering the disease.Recent studies suggest that abnormal activation of the NOD-like receptor thermal protein domain associated protein 3(NLRP3)inflammasome may play a critical role in the pathogenesis of MS.In this context,this review summarizes the molecular mechanisms underlying NLRP3 activation and its connection to MS,considering relevant literature from the past decade.The findings aim to provide insights into the progression of MS and to identify potential therapeutic strategies by elucidating the underlying mechanisms.