RCAS1/EBAG9 and P53 protein expressions in intrahepatic cholangiocarcinoma and the clinical significance
10.7659/j.issn.1005-6947.2019.08.007
- VernacularTitle:RCAS1/EBAG9与P53蛋白在肝内胆管癌中的表达及临床意义
- Author:
Yijun WANG
1
;
Ziqiang XU
;
Zhiming WANG
;
Dongyou YUE
;
Weijie YUAN
;
Ke XU
Author Information
1. 郴州市第一人民医院急诊科,湖南 郴州 423000
- Publication Type:Journal Article
- Keywords:
Bile Duct Neoplasms;
Bile Ducts,Intrahepatic;
Antigens,Neoplasm;
Prognosis
- From:
Chinese Journal of General Surgery
2019;28(8):952-959
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the protein expressions of RCAS1/EBAG9 and P53 in intrahepatic cholangiocarcinoma(ICC)tissue and their clinical significance.Methods:The protein expressions of RCAS1/EBAG9 and P53 in 41 specimens of ICC tissue and 9 specimens of normal bile duct tissue were detected by immunohistochemcal staining.The relations of RCAS1/EBAG9 and P53 protein expressions with the clinicopathologic characteristics and prognosis of the patients were analyzed.Results:The positive expression rates of both RCAS1/EBAG9 and P53 proteins in ICC tissue were significantly higher than those in normal bile duct tissue(both P<0.05).The RCAS1/EBAG9 protein expression was significantly related to tumor size,pathological grade,TNM stage and lymph node metastasis,while P53 protein expression was significantly associated with tumor size,pathological grade,and TNM stage(all P<0.05).There was a positive correlation between RCAS1/EBAG9 and P53 protein expression in ICC tissue(r=0.329,P=0.018).The overall postoperative survival time in patients with negative RCAS1/EBAG9 or P53 protein expression was significantly longer than that in patients with positive RCAS1/EBAG9 or P53 protein expression(χ2=3.862,P=0.049;χ2=4.977,P=0.026).Results of univariate and multivariate Cox regression analysis showed that RCAS1/EBAG9 protein expression was an independent risk factor for the prognosis of ICC patients(HR=3.657,95%CI=1.111-12.040,P=0.033).Conclusion:The RCAS1/EBAG9 and P53 protein expressions are increased in ICC tissue,and are closely associated with unfavorable clinicopathologic features and outcomes of the ICC patients,in which,the RCAS1/EBAG9 may probably play a causal role.
