Analysis of Risk Factors for Uremic Encephalopathy in Maintenance Hemodialysis Patients
10.13241/j.cnki.pmb.2025.16.008
- VernacularTitle:维持性血液透析患者尿毒症脑病发生的危险因素分析
- Author:
Hai-yan KANG
1
;
Zhi-yan TAN
;
Liu-yu TAN
;
Wei-guang LU
;
Qiong HUANG
;
Sheng-bao LONG
Author Information
1. 来宾市人民医院肾内科 广西来宾 546100
- Publication Type:Journal Article
- Keywords:
Maintenance hemodialysis;
Uremic encephalopathy;
Risk factors;
Infection;
Parathyroid hormone
- From:
Progress in Modern Biomedicine
2025;25(16):2630-2635
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the independent risk factors for uremic encephalopathy(UE)in maintenance hemodialysis(MHD)patients and provide evidence for early clinical warning and intervention.Methods:A case-control study was conducted,enrolling 67 MHD patients diagnosed with UE(UE group)at Laibin People's Hospital from January 2010 to December 2024,and 67 non-UE patients during the same period(control group).Demographic characteristics,dialysis parameters,laboratory indicators,and infection events were collected.Univariate and multivariate logistic regression analyses were used to identify independent risk factors for UE.Results:The UE group had significantly higher rates of infection(58.2％vs.29.9％),serum creatinine(789 vs.702 μmol/L),and iPTH levels(568 vs.385 pg/mL)compared to the control group(P＜0.05).Multivariate analysis revealed that concurrent infection(OR=3.022,95％CI:1.312-6.958),elevated serum creatinine(OR=1.004,95％CI:1.000-1.008),and elevated iPTH(OR=1.002,95％CI:1.001-1.003)were independent risk factors for UE(P＜0.05).The combined prediction model achieved an AUC of 0.878(95％CI:0.822-0.934),with 82.1％sensitivity and 80.6％specificity.Conclusion:Infection,elevated serum creatinine,and elevated iPTH significantly increase the risk of UE in MHD patients.Clinical management should emphasize infection prevention,toxin clearance optimization,and parathyroid function regulation to reduce UE incidence.
