Application of solid collagen-based materials in medical devices
- VernacularTitle:固态胶原基材料在医疗器械中的应用
- Author:
Zhangjie HU
1
;
Baoguan ZHANG
;
Zhiwu ZHANG
Author Information
- Publication Type:Journal Article
- Keywords: collagen; solid collagen; biological characteristics; medical devices; preparation technology; clinical application
- From: Chinese Journal of Tissue Engineering Research 2025;29(16):3503-3512
- CountryChina
- Language:Chinese
- Abstract: BACKGROUND:Collagen is the main component of extracellular matrix.With its stable triple helix structure,good biological characteristics and machinability,collagen is an ideal biomedical material and has been widely used in the field of medical devices.OBJECTIVE:To analyze the main product morphology,technical characteristics,preparation process,and clinical application of solid collagen-based materials.METHODS:The research on solid collagen-based materials in the field of medical devices included in PubMed and CNKI was searched by computer.The English and Chinese search terms were"collagen,collagen sponge,collagen membrane,collagen powder,collagen gel,decellularized extracellular martix,medical device,clinical application."After preliminary screening of all articles according to inclusion and exclusion criteria,92 articles with higher quality and relevance were retained for review.RESULTS AND CONCLUSION:Solid collagen-based materials from animal sources have been used as materials for the preparation of medical devices,and remarkable progress has been made in raw material extraction,preparation technology,and clinical application.Marine biological collagen and recombinant collagen have increased the selectivity of collagen sources.There are various types of solid collagen-based medical devices and various preparation methods,among which crosslinking modification is an important way to improve material properties,which is worthy of further study.In terms of product development ideas,research on solid collagen-based medical device products is developing in the direction of trivialization and biochemistry,and the research on compounding with other biological materials and drugs has also shown great potential.Although many collagen-based medical devices have been used clinically in China,product development in the fields of artificial skin,cartilage repair,and nerve injury repair is still insufficient,and further breakthroughs and innovations in technology and industrialization are needed.
