Advances in the role of lipid metabolism gene variants in the pathogenesis and personalized management of hyperlipidemic acute pancreatitis
10.7659/j.issn.1005-6947.250325
- VernacularTitle:脂代谢基因多态性在高脂血症型急性胰腺炎发病机制与个体化治疗中的研究进展
- Author:
Mengyu LI
1
;
Wei WEI
;
Min WANG
Author Information
1. 中南大学湘雅医院 内分泌科,湖南 长沙 410008;中南大学湘雅医院 国家老年医学临床研究中心,湖南 长沙 410008
- Publication Type:Journal Article
- Keywords:
Pancreatitis;
Hyperlipidemias;
Lipid Metabolism;
Polymorphism,Genetic;
Precision Medicine;
Review
- From:
Chinese Journal of General Surgery
2025;34(7):1542-1552
- CountryChina
- Language:Chinese
-
Abstract:
Hyperlipidemic acute pancreatitis(HLAP)is triggered by severe disturbances in lipid metabolism,progresses rapidly,and is associated with a high risk of complications.Its pathogenesis involves multiple mechanisms,including chylomicron accumulation and free fatty acid toxicity,activation of inflammatory pathways,and disruption of intracellular calcium homeostasis.Recent studies have shown that polymorphisms in lipid metabolism-related genes can influence HLAP susceptibility,disease severity,and lipid-lowering drug efficacy by regulating lipoprotein metabolism,fatty acid oxidation,and inflammatory responses.This article systematically reviews the associations between major lipid metabolism gene polymorphisms and HLAP/hypertriglyceridemia,gene-gene and gene-environment interactions,and the potential impact of these polymorphisms on the therapeutic responses to fibrates,statins,and PCSK9 inhibitors.It also discusses the current status and challenges of genotype-based individualized prevention and treatment strategies,aiming to provide a theoretical basis and future directions for precision screening and personalized management of HLAP.
