Application Value of Dyclonine Hydrochloride Mucilage in Bowel Preparation for Colonoscopy:A Randomized Double-blinded Placebo-controlled Study
10.3969/j.issn.1008-7125.2025.01.003
- VernacularTitle:盐酸达克罗宁胶浆在结肠镜检查肠道准备中的应用价值:一项随机、双盲、安慰剂对照研究
- Author:
Peng CHENG
1
;
Zhengrong ZHONG
;
Qingqi CHEN
;
Caituan FENG
;
Yuanchao WU
;
Xiangjun MENG
;
Dong WANG
Author Information
1. 海南西部中心医院(上海交通大学医学院附属第九人民医院海南分院)消化内科(571799);上海市消化道微生态及相关重大疾病研究重点实验室 上海交通大学消化疾病研究与临床转化中心 上海交通大学医学院附属第九人民医院消化内科
- Publication Type:Journal Article
- Keywords:
Dyclonine Hydrochloride Mucilage;
Colonoscopy;
Polyethylene Glycols;
Bowel Preparation;
Bubbles;
Adenoma
- From:
Chinese Journal of Gastroenterology
2025;30(1):16-21
- CountryChina
- Language:Chinese
-
Abstract:
Background:Ideal bowel preparation is the prerequisite for the successful diagnostic and therapeutic colonoscopy.The retention of intestinal bubbles can seriously affect the clarity of the intestinal mucosa and subsequently decrease the detection rate of colonoscopy.Aims:To investigate the application value of dyclonine hydrochloride mucilage in bowel preparation for colonoscopy.Methods:This study was a randomized double-blinded placebo-controlled trial.Patients who underwent colonoscopy from October 2020 to October 2023 at Hainan West Central Hospital were enrolled and randomly allocated into the dyclonine hydrochloride mucilage group and the control group.3 L polyethylene glycol(PEG)+dyclonine hydrochloride mucilage and 3 L PEG+placebo were given for bowel preparation,respectively.The quality of bowel preparation was evaluated by Boston bowel preparation scale(BBPS)score and bubble score.Furthermore,a questionnaire was conducted.The cecal intubation time,withdrawal time,adenoma detection rate and adverse reaction were compared between the two groups.Results:A total of 482 patients who underwent colonoscopy were included.No significant differences in clinical characteristics such as gender,age,body mass index(BMI)and main reasons for colonoscopy were found between the dyclonine hydrochloride mucilage group and the control group(all P>0.05).Compared with the control group,no significant differences existed in total BBPS score and segment scores for right,transverse,and left colon in the dyclonine hydrochloride mucilage group(all P>0.05),but the total bubble score and segment scores for right,transverse,and left colon were significantly decreased(all P<0.001).The withdrawal time in the dyclonine hydrochloride mucilage group was significantly decreased compared to the control group(P<0.001),and the adenoma detection rate was significantly increased(P=0.001).However,no significant differences in cecal intubation time and incidence of adverse reaction were found between the two groups(all P>0.05).Conclusions:Administration of dyclonine hydrochloride mucilage during bowel preparation for colonoscopy can reduce the formation of intestinal bubbles,shorten the withdrawal time and increase the adenoma detection rate.
