Strategies and future prospects for the prevention and treatment of ischemia-reperfusion injury in liver graft
10.12464/j.issn.1674-7445.2025217
- VernacularTitle:肝移植物缺血-再灌注损伤的防治策略与未来展望
- Author:
Wei LI
1
;
Yuan AN
1
;
Lianyue GUAN
1
Author Information
1. 130033 长春,吉林大学中日联谊医院肝胆胰外科吉林省肝胆胰肿瘤精准诊治工程实验室
- Publication Type:Journal Article
- Keywords:
Liver graft;
Liver ischemia-reperfusion injury;
Organ preservation;
Machine perfusion;
Targeted drug;
Early allograft dysfunction;
Expanded criteria donor;
Reactive oxygen species
- From:
Organ Transplantation
2025;16(5):701-709
- CountryChina
- Language:Chinese
-
Abstract:
Ischemia-reperfusion injury(IRI)of the donor liver is inevitable during procurement,preservation and transplantation,directly affecting the outcome of liver transplantation.It is the main cause of early allograft dysfunction and acute/chronic graft rejection after liver transplantation.It is also the main risk factor that affects the use of marginal grafts and exacerbates donor shortage.With the rapid development of biomedical technology,continuous improvements have been made in donor liver preconditioning,preservation perfusion techniques,and pharmacological treatments.Particularly significant progress and breakthroughs have been achieved in the areas of machine perfusion technology,ischaemia-free liver transplantation,anti-oxidation,anti-apoptosis and anti-inflammatory treatments.These advances have significantly reduced or prevented IRI in donor livers,extended the preservation time of donor livers ex vivo,reduced a series of severe complications after liver transplantation,and also significantly increased the utilization rate of marginal donor livers.This article discusses the progress in mechanisms related to liver IRI and liver preservation methods,and explores existing issues,cutting-edge explorations,and future challenges in effective organ preservation and optimization.
