A study on bergapten anti-inflammatory inhibition of bone resorption in the treatment of periodontitis
10.13591/j.cnki.kqyx.2025.09.005
- VernacularTitle:佛手柑内酯抗炎抑制骨吸收治疗牙周炎的研究
- Author:
Yuhan JIANG
1
;
Pinzhe YOU
1
;
Xueyun ZHAO
1
;
Mohan LIN
1
;
Bowei SHI
1
;
Junlin PU
1
;
Bo JIA
1
Author Information
1. 长沙医学院口腔医学院基础教研室,湖南 长沙(410000)
- Publication Type:Journal Article
- Keywords:
periodontitis;
bergapten;
anti-inflammatory;
inhibition of bone resorption
- From:
STOMATOLOGY
2025;45(9):667-674
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the anti-inflammatory properties of bergaptenand its inhibition of bone resorption in the treatment of periodontitis,as well as its potential underlying mechanisms.Methods A total of 35 male Wistar rats were randomly di-vided into five groups(control group,model group,and low-,medium-,and high-dose bergapten groups,with 7 rats in each group).Except for the control group,periodontitis was induced in all other groups by orthodontic ligation of the bilateral maxillary first molars(M1)and feeding a high-sugar diet.After successful modeling,the control and model groups received gavage of isotonic saline,while the bergapten groups received gavage of 50,100,and 200 mg/kg bergapten,respectively,once daily for 4 consecutive weeks.Perio-dontal symptoms were observed,and GI,SBI grades,and PLI scores were recorded.Rats were sacrificed within 24 hours after the last administration,and their maxillae were immediately subjected to Micro-CT scanning to assess alveolar bone resorption.Histopathological changes in the periodontal tissues were observed using HE staining,and serum levels of pro-inflammatory cytokines(IL-6 and IL-1β)were measured by ELISA.Results Compared with the control group,the model group exhibited significantly higher levels of IL-6,IL-1β,GI,SBI grades,PLI scores,and CEJ-ABC distance,while bone volume to total volume ratio(BV/TV),trabec-ular number(Tb.N),and trabecular thickness(Tb.Th)were significantly reduced(P＜0.001).In comparison to the model group,the bergapten groups(with the exception of the low-dose group for IL-6)demonstrated reductions in IL-6,IL-1β levels,GI,SBI grades,PLI scores,and CEJ-ABC distance,with the medium-dose group showing the most pronounced effect(except for IL-6).Conclusion Bergapten can effectively prevent and treat periodontitis by inhibiting the secretion of IL-6 and IL-1β cytokines,achieving anti-inflam-matory effects and inhibiting bone resorption.
