Dyspnea, limb numbness, and arrhythmia due to apatinib
10.3760/cma.j.cn114015-20210425-00499
- VernacularTitle:阿帕替尼致呼吸困难、四肢麻木和心律失常
- Author:
Huabo WEI
1
;
Junguo ZHANG
;
Bing TAN
;
Yang DONG
Author Information
1. 重庆市丰都县人民医院药剂科，丰都 408299
- Publication Type:Journal Article
- Keywords:
Carcinoma, squamous cell;
Dyspnea;
Arrhythmias, cardiac;
Hand-foot-skin reaction syndrome;
Apatinib
- From:
Adverse Drug Reactions Journal
2022;24(3):150-152
- CountryChina
- Language:Chinese
-
Abstract:
A 65-Year-old male patient with squamous cell lung cancer received chemotherapy with paclitaxel (210 mg by an IV infusion on day 1) and carboplatin (0.5 g by an IV infusion on day 1; 21 days was a cycle) and targeted therapy with apatinib (0.25 g orally once daily). About 1 hour after the first oral administration of apatinib, the patient developed dyspnea, chest tightness, followed by limb numbness and fatigue. About 1 hour after the second administration, the above symptoms recurred, accompanied by lower limb pain, speak disability, and arrhythmia. The symptoms were considered to be related to apatinib. The drug was stopped and the treatments including noninvasive ventilator assisted breathing, antiallergic, antispasmodic, and antiasthmatic were given. Five days later, the above symptoms disappeared.
