Major signaling pathways involved in skin wound repair by mesenchymal stem cell-derived exosomes
10.3760/cma.j.cn114453-20240619-00160
- VernacularTitle:间充质干细胞来源外泌体参与皮肤创面修复的主要信号通路
- Author:
Yichen WANG
1
;
Hongfan DING
;
Jide JIN
;
Minliang CHEN
;
Xiao XU
Author Information
1. 解放军总医院第四医学中心烧伤整形医学部，北京 100048
- Publication Type:Journal Article
- Keywords:
Stem cells;
Exosomes;
Mesenchymal stem cell;
Wound healing;
Signal pathway
- From:
Chinese Journal of Plastic Surgery
2025;41(3):307-318
- CountryChina
- Language:Chinese
-
Abstract:
The skin is one of the most vital organs in the human body, and skin wounds caused by various factors can severely impact patients’ physical and mental health. Among the therapeutic strategies for skin wound repair, mesenchymal stem cell-derived exosomes (MSC-Exos) have emerged as a promising biological therapy, attracting significant attention in related research. As critical mediators of stem cell biological effects, MSC-Exos fuse with target cells and transfer bioactive proteins and nucleic acids from stem cells into recipient cells. These exosomes modulate inflammatory responses, promote cell proliferation, migration, and angiogenesis, and regulate extracellular matrix remodeling, thereby accelerating wound healing. In recent years, studies on the mechanisms by which exosomes promote skin wound repair have advanced and refined continuously. This article summarized the key signaling pathways through which MSC-Exos participate in skin wound repair, aiming to enhance the understanding of their roles in facilitating wound healing.
