Ethinylestradiol and cyproterone acetate tablets-induced deep vein thrombosis complicated with subacute pulmonary embolism in a patient with antiphospholipid syndrome
10.3760/cma.j.cn114015-20210226-00232
- VernacularTitle:炔雌醇环丙孕酮片诱发抗磷脂综合征患者下肢深静脉血栓和亚急性肺栓塞
- Author:
Zhengyue QIAN
1
;
Xiuhong ZHANG
1
Author Information
1. 南京医科大学附属无锡市人民医院药学部，无锡 214023
- Publication Type:Journal Article
- Keywords:
Antiphospholipid syndrome;
Contraceptive agents;
Venous thromboembolism;
Pulmonary embolism;
Ethinylestradiol and cyproterone acetate
- From:
Adverse Drug Reactions Journal
2021;23(12):658-660
- CountryChina
- Language:Chinese
-
Abstract:
A 16-year-old female patient received ethinylestradiol and cyproterone acetate tablets (1 tablet once daily for 21 days) for artificial menstrual cycle treatment due to irregular menstruation. On the 7th day of medication, the patient developed swelling of the distal right lower extremity, accompanied by pain, and slight limitation of movement, which did not attract attention. The drug was stopped 21 days later. On the 2nd day after drug withdrawal, the patient had vaginal withdrawal bleeding and blood expectoration occurred once on the same day. After 16 days of drug withdrawal, the swelling and pain of the right lower limb was aggravated. Ultrasound showed deep vein thrombosis in the right lower limb, and CT angiography of the pulmonary artery showed embolism in the right lower pulmonary artery. Deep vein thrombosis complicated with subacute pulmonary embolism were diagnosed. Enoxaparin sodium for anticoagulation and symptomatic treatments were given, the symptoms were improved 17 days later. Laboratory tests showed that the platelet count was 90×10 9/L, the anticardiolipin antibody IgG was 209 GPL/ml, and the platelet-related antibody was positive. Antiphospholipid syndrome was diagnosed. It was considered that the thrombosis was related to ethinylestradiol and cyproterone acetate tablets.
