Bullous pemphigoid after long-term use of rifampin
10.3760/cma.j.cn114015-20210705-00748
- VernacularTitle:长期应用利福平诱发大疱性类天疱疮
- Author:
Xianshu FEI
1
;
Jing GUO
1
;
Xueqi LI
1
;
Fei CHEN
1
;
Feishen LIN
1
Author Information
1. 南京中医药大学附属南京医院（南京市第二医院）结核科，南京 200013
- Publication Type:Journal Article
- Keywords:
Rifampin;
Pemphigoid, bullous;
Case report
- From:
Adverse Drug Reactions Journal
2021;23(12):655-657
- CountryChina
- Language:Chinese
-
Abstract:
A 72-year-old male patient with secondary pulmonary tuberculosis developed skin erythema and pruritus of both lower limbs after 10 months of antituberculosis treatment with isoniazid, rifampin, ethambutol, and pyrazinamide, followed by blisters and bullae, and the skin lesions gradually spread to his whole body. The skin biopsy showed bullous pemphigoid, and the antibodies to bullous pemphigoid 180 detected by enzyme-linked immunosorbent assay was 156.8 U/ml. Considering that the patient′s bullous pemphigoid might be induced by rifampin, rifampin was discontinued and antitu-berculosis therapy was changed to isoniazid, ethambutol, pyrazinamide, and moxifloxacin. Prednisone acetate and symptomatic and supportive treatments were given at the same time. Two weeks later, the lesions were markedly improved, and the original erosive surface got scabs and basically healed. At 6 months of follow-up, the lesions recovered, and no new lesions or blisters occurred.
