Hepatic arterial infusion chemotherapy for colorectal liver metastasis
10.3969/j.issn.1005-6483.20241000
- VernacularTitle:肝动脉灌注化疗治疗结直肠癌肝转移
- Author:
Yan SUN
1
;
Zheng WANG
1
;
Quanda LIU
1
Author Information
1. 100053 北京,中国中医科学院广安门医院外科
- Publication Type:Journal Article
- Keywords:
hepatic arterial infusion chemotherapy;
colorectal liver metastasis;
therapeutics
- From:
Journal of Clinical Surgery
2025;33(8):887-889
- CountryChina
- Language:Chinese
-
Abstract:
Hepatic arterial infusion chemotherapy(HAIC)is a therapeutic strategy that delivers chemotherapy drugs directly to the liver through the hepatic arterial system,which enriches the concentration of the drug in the liver to 400 times of the systemic intravenous administration.It has the significant advantage of maximizing the concentration of liver local chemotherapy drugs,while reducing systemic side effects.HAIC plus intravenous chemotherapy has shown promising results in conversion to resection and survival rate for metastatic liver cancer,especially for initially unresectable colorectal liver metastasis.The primary tumor and liver metastasis can be simultaneously addressed by combined transcatheter arterial infusion chemotherapy with chemoembolization,which can rapidly reduce tumor burden,ameliorate clinical symptoms of gastrointestinal hemorrhage and incomplete intestinal obstruction.To date,though,there is no consensus on the definitive indication,medication regimen and multi-method combination therapy.This article discusses the basic principle,technical methods,clinical application and current research progress of HAIC.
