Severe allergic reaction and acute respiratory failure due to dyclonine hydrochloride mucilage
10.3760/cma.j.cn114015-20200519-00558
- VernacularTitle:盐酸达克罗宁胶浆致严重过敏反应并急性呼吸衰竭
- Author:
Ling GU
1
;
Wenyi BAO
;
Jian QIAN
Author Information
1. 江苏省泰兴市人民医院药学部，泰兴 225400
- Publication Type:Journal Article
- Keywords:
Anaphylaxis;
Respiratory insufficiency;
Dacronine
- From:
Adverse Drug Reactions Journal
2021;23(2):108-109
- CountryChina
- Language:Chinese
-
Abstract:
An 87-year-old male patient was scheduled for electronic laryngoscopy examination due to pharyngeal discomfort. Before the examination, he was anesthetized locally with 10 ml dyclonine hydrochloride mucilage in his mouth and vomited out 5 minutes later. After spitting out the medicine, the patient developed shortness of breath, fatigue, and dyspnea suddenly 5 minutes later; cold sweat and syncope appeared 20 minutes later; his pulse oximeter oxygen saturation (SpO 2) decreased to 0.50 and unconsciousness appeared 30 minutes later. Severe allergic reaction was diagnosed, which mainly manifested as acute respiratory failure and might be related to dyclonine hydrochloride mucilage. Endotracheal intubation and ventilator assisted ventilation were performed immediately, and anti-infection, expectorant, nutritional support, stable internal environment maintaining treatments were given at the same time. After 6 days′ treatments, the endotracheal intubation was removed and the nasal tube was used for oxygen inhalation. Then the SpO 2 was 0.99 and the above-mentioned symptoms disappeared.
