Parameters of MR diffusion kurtosis imaging for predicting human epidermal growth factor receptor 2-positive breast cancer
10.13929/j.issn.1672-8475.2025.08.008
- VernacularTitle:MR弥散峰度成像参数预测人表皮生长因子受体-2阳性乳腺癌
- Author:
Jinxia QIU
1
;
Yongbo YIN
;
Lili YANG
;
Na QI
;
Hongsha WANG
Author Information
1. 邢台市人民医院放射科,河北 邢台 054031
- Publication Type:Journal Article
- Keywords:
breast neoplasms;
ErbB receptors;
diffusion magnetic resonance imaging;
diagnosis
- From:
Chinese Journal of Interventional Imaging and Therapy
2025;22(8):529-533
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the value of parameters of MR diffusion kurtosis imaging(DKI)for predicting human epidermal growth factor receptor 2(HER2)-positive breast cancer(BC).Methods A total of 122 cases of BC diagnosed by pathology were retrospectively enrolled,including 37 cases of HER2-positive(HER2-positive group)and 85 cases of HER2-negative(HER2-negative group).Parameters obtained based on MR DKI(mean diffusivity[MD]and mean kurtosis[MK]values)and the results of immunohistochemical detection(expression of matrix metalloproteinase-2[MMP-2],vascular endothelial growth factor receptor 2[VEGFR-2])were compared between groups.Then maltivariable logistic regression was used to analyze the independent predictors of HER2-positive BC based on DKI parameters being statistically different between groups,and a combined model was constructed.Receiver operating characteristic(ROC)curve was drawn,and the area under the curve(AUC)were calculated to assess the efficacy of each single DKI parameter and their combined model for predicting HER2-positive BC,and the correlations of these DKI parameters with MMP-2 or VEGFR-2 expressions were analyzed.Results Compared with HER2-negative group,MD value,MK value,positive expression proportion of MMP-2 and VEGFR-2 increased in HER2-positive group(all P＜0.05).Both MD(OR=1.423)and MK(OR=1.624)values were independent predictors of HER2-positive BC(both P＜0.05),with AUC for predicting HER2-positive BC of 0.819 and 0.836,respectively,while the AUC of combined model of MD and MK values was 0.916.MD value of BC was positively correlated with MMP-2(rs=0.222)and VEGFR-2 expression(rs=0.232)(both P＜0.05),while MK value of BC was not significantly correlated with MMP-2 or VEGFR-2 expression(both P＞0.05).Conclusion As parameters of MR DKI,MD and MK values could be used to effectively predict HER2-positive BC.
