Adefovir dipivoxil-induced hypophosphatemic osteomalacia
10.3760/cma.j.cn114015-20200929-01001
- VernacularTitle:阿德福韦酯致低磷性骨软化症
- Author:
Xin WANG
1
;
Qiang ZAN
;
Hui LI
Author Information
1. 陕西中医药大学第一临床医学院中医骨伤科学专业，咸阳 712046
- Publication Type:Journal Article
- Keywords:
Nucleotides;
Hypophosphatemia;
Osteomalacia;
Adefovir
- From:
Adverse Drug Reactions Journal
2021;23(3):156-157
- CountryChina
- Language:Chinese
-
Abstract:
A 50-year-old male patient was treated with adefovir dipivoxil 10 mg/d once daily for chronic hepatitis B. Seven years later, the patient developed multiple bone pains all over the body, which were gradually aggravated and restricted his movements. X-ray, CT, and magnetic resonance imaging examinations showed old fractures of the left 8th rib and the right 7th rib and fracture of the right femoral neck. Laboratory tests showed that serum creatinine was 111 μmol/L, serum phosphorus was 0.41 mmol/L, and alkaline phosphatase was 216 U/L. Bone mineral density examination showed osteoporosis in the 1st to 4th lumbar vertebrae, femoral necks, and total hipbones. Adefovir dipivoxil-induced hypophosphatemia was diagnosed. Adefovir dipivoxil was discontinued and replaced by entecavir, and oral phosphorus supplementation was given. After 2 months of treatments, the patient′s symptoms were improved. After 6 months of treatments, the bone pain basically disappeared and alkaline phosphatase, serum creatinine, and phosphorus returned to normal.
