MRI parameters of carotid artery plaque combined with low density lipoprotein cholesterol/high density lipoprotein cholesterol ratio for predicting ischemic stroke in young adults
10.13929/j.issn.1672-8475.2025.08.003
- VernacularTitle:颈动脉斑块MRI参数联合低密度脂蛋白胆固醇/高密度脂蛋白胆固醇比值预测青年缺血性卒中
- Author:
Chaoyan LIU
1
;
Xinjing SHI
;
Fang CHAI
;
Xinying WANG
;
Zhilei KANG
;
Bing LIU
Author Information
1. 衡水市人民医院影像中心,河北 衡水 053000
- Publication Type:Journal Article
- Keywords:
stroke;
magnetic resonance imaging;
cholesterol,LDL;
cholesterol,HDL;
forecasting;
prospective studies
- From:
Chinese Journal of Interventional Imaging and Therapy
2025;22(8):507-511
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the predictive value of MRI parameters of carotid artery plaque combined with low density lipoprotein cholesterol/high density lipoprotein cholesterol(LDL-C/HDL-C)ratio for predicting ischemic stroke in young patients with carotid atherosclerosis.Methods Totally 125 young patients with carotid atherosclerosis were prospectively included and divided into stroke group and non-stroke group based on whether ischemic stroke occurred within 3 months.Clinical data,laboratory indicators and carotid plaque-related MRI parameters were compared between groups.Based on carotid plaque-related MRI parameters being statistically different between groups,combined model 1 was constructed using multivariable logistic regression analysis,while combined model 2 was constructed combined with LDL-C/HDL-C ratio.The efficacy of each parameter and model for predicting ischemic stroke in young adults was analyzed.Results There were 48 cases in stroke group and 77 cases in non-stroke group.The levels of glycosylated hemoglobin,LDL-C,LDL-C/HDL-C ratio,carotid artery stenosis rate,plaque eccentricity index and plaque enhancement rate in stroke group were all higher than those in non-stroke group(all P＜0.05).The area under the curve(AUC)of LDL-C/HDL-C ratio,carotid artery stenosis rate,plaque eccentricity index,plaque enhancement rate,combined model 1 and 2 for predicting ischemic stroke in young adults was 0.816,0.757,0.768,0.805,0.883 and 0.936,respectively,of combined model 1 was higher than those of single parameter(all P＜0.05),while of combined model 2 was higher than that of combined model 1(Z=2.336,P=0.020).Conclusion MRI parameters of carotid artery plaque combined with LDL-C/HDL-C ratio could effectively predict ischemic stroke in young patients with carotid atherosclerosis.
