Effects of sufentanil combined with dezocine on serum cortisol, norepinephrine, epinephrine and adrenocorticotropic hormone levels in patients undergoing thyroid surgery
10.3760/cma.j.cn115455-20230922-00295
- VernacularTitle:舒芬太尼复合地佐辛术后镇痛对行甲状腺手术患者血清皮质醇、去甲肾上腺素、肾上腺素及促肾上腺皮质激素水平的影响
- Author:
Lingling LONG
1
;
Peipei LIU
;
Min YANG
;
Dinghang WU
Author Information
1. 恩施土家族苗族自治州中心医院麻醉科，恩施 445000
- Publication Type:Journal Article
- Keywords:
Sufentanil;
Dezocine;
Anesthesia and analgesia;
Safety
- From:
Chinese Journal of Postgraduates of Medicine
2025;48(4):369-372
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the effects of sufentanil combined with dezocine on serum cortisol(Cor), norepinephrine (NE), epinephrine (E) and adrenocorticotropic hormone (ACTH) levels in patients undergoing thyroid surgery.Methods:A total of 116 patients who underwent elective thyroid surgery in the Enshi Tujia and Miao Autonomous Prefecture Central Hospital from July 2019 to November 2021 were retrospectively selected. All patients were given mechanical analgesia pump for postoperative analgesia, and were divided into the control group (58 cases) and the observation group (58 cases) according to different drug formulations. The control group was given sufentanil + tropisetron hydrochloride for postoperative analgesia. Postoperative analgesia in the observation group was administrated with dezocine + sufentanil + tropisetron hydrochloride. The postoperative pain and sedation of the two groups were observed, and the levels of serum Cor, NE, E and ACTH and the occurrence of adverse reactions were compared between the two groups.Results:The visual analogue scale (VAS) scores in the observation group at 2, 6, 12 and 24 h after operation were lower than those in the control group, and the Ramsay scale scores were higher than those in the control group, there were statistical differences ( P<0.05). After operation, the levels of Cor, NE, E and ACTH in the observation group were lower than those in the control group: (857.81 ± 186.30) nmol/L vs. (1 082.20 ± 169.64) nmol/L, (1 469.40 ± 201.47) pmol/L vs. (1 548.42 ± 202.59) pmol/L, (498.17 ± 69.56) pmol/L vs. (630.47 ± 73.55)pmol/L, (15.35 ± 3.88) pmol/L vs. (17.36 ± 4.03) pmol/L, there were statistical differences ( P<0.05). The incidence of adverse reactions in the observation group was lower than that in the control group:12.07% (7/58) vs. 32.76% (19/58), there was statistical difference ( χ2 = 7.14, P<0.01). Conclusions:Sufentanil combined with dezocine for postoperative analgesia in patients undergoing thyroid surgery can exert sedative and analgesic effects by adjusting serum Cor, NE, E and ACTH levels, and reduce stress response, with good safety.
