Application of organoids in liver diseases research
10.3760/cma.j.cn115610-20250121-00031
- VernacularTitle:类器官在肝脏疾病研究中的应用
- Author:
Jiarui HE
1
;
Yongnan LI
;
Jian LI
;
Linyan ZHOU
;
Zuoyi JIAO
Author Information
1. 兰州大学第二医院普通外科，兰州 730030
- Publication Type:Journal Article
- Keywords:
Liver diseases;
Organoid;
Disease modeling;
Stem cells;
Precision medicine
- From:
Chinese Journal of Digestive Surgery
2025;24(5):657-664
- CountryChina
- Language:Chinese
-
Abstract:
The liver is one of the important metabolic organs in the body, and liver diseases are also one of the major public health issues globally. Currently, the lack of models that accurately simulating human physiology and pathology is the key challenge in liver disease research, and the emerging of organoid technology is an excellent solution to this challenge. Organoids are three-dimensional cellular structures cultured in vitro that can mimic the structure and function of real organs while maintaining genetic stability. The development of organoids has provided possibilities for personalized medicine and precision therapy and has become a key tool in the research and treatment of liver diseases. The authors focuse on the application and development of organoids in liver disease research, while also emphasizing their limitations and future prospects.
