Research advances of immune checkpoint inhibitors for neoadjuvant therapy in locally advanced gastric cancer
10.3760/cma.j.cn115610-20250827-00559
- VernacularTitle:免疫检查点抑制剂在局部进展期胃癌新辅助治疗中的研究进展
- Author:
Ying SHA
1
;
Ke YU
;
Jiajia JIA
;
Yufan TANG
;
Bingbing WEN
;
Baiquan ZHOU
;
Shumei XU
;
Ruifang FAN
Author Information
1. 西北民族大学医学部，兰州 730030
- Publication Type:Journal Article
- Keywords:
Stomach neoplasms;
Locally advanced;
Neoadjuvant therapy;
Immuno-therapy;
Immune checkpoint inhibitors
- From:
Chinese Journal of Digestive Surgery
2025;24(9):1214-1220
- CountryChina
- Language:Chinese
-
Abstract:
Gastric cancer is one of the most common malignant tumors in the digestive system, characterized by high incidence and mortality rates. In recent years, with the rapid develop-ment of molecular immunology, the application of immune checkpoint inhibitors (ICIs) in neoadju-vant therapy has significantly improved pathological response rates and survival outcomes for patients with resectable locally advanced gastric cancer. The authors systematically review current research progress on combination strategies involving immune checkpoint inhibitors in neoadjuvant therapy for locally advanced gastric cancer, aiming to provide an evidence for optimizing individua-lized therapeutic regimens.
