Acute liver injury induced by Yinaoning tablets (益脑宁片)
10.3760/cma.j.cn114015-20180813-00787
- VernacularTitle:益脑宁片致急性肝损伤
- Author:
Changlong SHEN
1
;
Shuangnan FU
;
Kun ZHOU
;
Man GONG
;
Li YU
;
Tingting HE
Author Information
1. 延边中医医院延吉市中医医院肝胆脾胃科，吉林延吉 133000
- Publication Type:Journal Article
- Keywords:
Chemical and drug induced liver injury;
Polygonum multiflorum;
Yinaoning tablets
- From:
Adverse Drug Reactions Journal
2020;22(4):268-269
- CountryChina
- Language:Chinese
-
Abstract:
A 52-year-old male patient received self-purchased Yinaoning tablets (益脑宁片) (3 tablets, trice daily) orally for health care. On day 18 of medication, the patient developed jaundiced skin and sclera and dark urine. On day 24, he developed fatigue and anorexia. Laboratory tests showed alanine aminotransferase (ALT) 1 132 U/L, aspartate aminotransferase (AST) 953 U/L, total bilirubin (TBil) 80.0 μmol/L, direct bilirubin (DBil) 73.4 μmol/L, alkaline phosphatase (ALP) 203 U/L, and gamma-glutamyltransferase (γ-GT) 155 U/L. Acute liver injury induced by Yinanning tablets was considered. Then the drug was discontinued and liver-protective therapy and drugs for anti-jaundice were given. On day 6 of drug withdrawal, the laboratory tests showed ALT 192 U/L, AST 158 U/L, TBil 51.0 μmol/L, DBil 39.9 μmol/L, ALP 178 U/L, and γ-GT 149 U/L, his appetite recovered, and the yellowish skin and sclera improved markedly. On day 13 of drug withdrawal, his yellowish skin and sclera disappeared, and the laboratory tests showed ALT 56 U/L, AST 62 U/L, TBil 30.7 μmol/L, DBil 22.4 μmol/L, ALP 164 U/L, and γ-GT 142 U/L. At 6 months of follow-up, there were no abnormalities in his liver function.
