Acute liver injury due to Gukang capsules (骨康胶囊) , Jieguqili pills (接骨七厘丸) , and ibuprofen and codeine phosphate tablets
10.3760/cma.j.cn114015-20181206-01210
- VernacularTitle:骨康胶囊、接骨七厘丸和洛芬待因片致急性肝损伤
- Author:
Huiwei XU
1
;
Haiwen WU
;
Yingqing XU
;
Haiying YU
;
Yan ZHOU
Author Information
1. 宁波市药品不良反应监测中心 315042
- Publication Type:Journal Article
- Keywords:
Chemical and drug induced liver injury;
Gukang capsules;
Jieguqili pills;
ibuprofen and codeine phosphate tablets
- From:
Adverse Drug Reactions Journal
2020;22(5):323-325
- CountryChina
- Language:Chinese
-
Abstract:
A 66-year-old female patient received Gukang capsules and Jieguqili pills orally for 11 days for fracture. On day 6 after the drugs withdrawal, she developed weakness, anorexia, and yellow urine. Drugs above-mentioned were re-given and ibuprofen and codeine phosphate tablets were added. Five days later, her symptoms were aggravated. Laboratory tests showed alanine aminotransferase (ALT) 778 U/L, aspartate aminotransferase (AST) 782 U/L, alkaline phosphatase (ALP) 151 U/L, total bilirubin (TBil) 34.3 μmol/L, direct bilirubin (DBil) 24.0 μmol/L, and gamma-glutamyltransferase (γ-GT) 111 U/L. It was considered to be liver injury caused by Gukang capsules, Jieguqili pills, and ibuprofen and codeine phosphate tablets. All drugs above were withdrawn and the liver-protective and anti-jaundice treatments were given. After 21 days, laboratory tests showed ALT 24 U/L, AST 17 U/L, ALP 104 U/L, TBil 13.6 μmol/L, DBil 9.0 μmol/L, and γ-GT 52 U/L.
