Mass Transfer in a Curved Hollow Fiber Bioreactor for Artificial Liver
10.16156/j.1004-7220.2024.06.027
- VernacularTitle:人工肝弯曲形中空纤维反应器内传质动力学
- Author:
Ziheng WANG
1
;
Shaofeng XU
;
Yifan YU
;
Zichen WANG
;
Xuechang ZHANG
Author Information
1. 浙大宁波理工学院 机电与能源工程学院,浙江 宁波 315100;浙江理工大学 机械工程学院,杭州 310018
- Publication Type:Journal Article
- Keywords:
artificial liver;
hollow fiber bioreactor;
Dean vortices;
transmembrane pressure;
mass transfer
- From:
Journal of Medical Biomechanics
2024;39(6):1204-1211
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect of a curved hollow-fiber bioreactor on the mass transfer in an artificial liver to provide references for the optimal design of new bioreactor structures and operation parameters for clinical treatment.Methods A computational fluid dynamics(CFD)model of a hollow fiber bioreactor was established using numerical simulation.The diffusion and convection mass transfer in the hollow fiber bioreactor were considered by the K-K equation and Darcy's law.The effects of the bending count and bending amplitude on the mass transfer behavior in a hollow fiber bioreactor were analyzed.Results Dean vortices were generated in the curved hollow fiber bioreactor owing to the centrifugal force.This promoted solute remixing in the tube and thereby,diffusion mass transfer.Meanwhile,the higher transmembrane pressure in the curved hollow fiber bioreactor also promoted convection mass transfer.Consequently,the Dean vortices and high transmembrane pressure increased the solute clearance rate.When the bending counts were 0,3,6,9,and 12 and the bending amplitude was 1 mm,the bilirubin clearance rates were 113.44,117.95,121.89,129.89,and 140.57 mL/min respectively.When the bending amplitudes were 0,0.5,1.0,1.5,and 2.0 mm and the bending count was three,the bilirubin clearance rates were 113.44,115.45,117.95,120.16,and 123.14 mL/min,respectively.Conclusions The curved hollow fiber bioreactor improved the toxin removal efficiency in the artificial liver.
