Progress in post-translational modification and molecular mechanism of MGP as a vascular calcification inhibitor
10.3969/j.issn.1000-4718.2024.12.021
- VernacularTitle:MGP翻译后修饰及其抑制血管钙化分子机制的研究进展
- Author:
Minwen HONG
1
;
Qingfeng LI
;
Kang LIU
;
Dan LIANG
;
Shixin LI
;
Zhenyu HAO
Author Information
1. 扬州大学生物科学与技术学院,江苏 扬州 225009
- Publication Type:Journal Article
- Keywords:
matrix gamma-carboxyglutamate protein;
post-translational modification;
calcification inhibition
- From:
Chinese Journal of Pathophysiology
2024;40(12):2359-2366
- CountryChina
- Language:Chinese
-
Abstract:
The matrix gamma-carboxyglutamate protein(MGP),a vitamin K-dependent protein,inhibits arte-rial calcification.The substance's ability to inhibit calcification is linked to its post-translational modifications,specifical-ly γ-glutamyl carboxylation and phosphorylation.The molecular mechanism of the calcification inhibitor remains unclear due to its low solubility and complicated post-translational modifications.In this section,we summarize current research and ongoing debates about post-translational modifications of MGP and its mechanism for inhibiting calcification.We re-viewed recent research on diseases associated with MGP deficiency,such as cardiovascular disease,chronic kidney dis-ease,and Keutel syndrome.Hopefully,this review can help us understand how MGP functions as a vascular calcification inhibitor and identify potential treatments for diseases resulting from its dysfunction.
