Advances in role of CRAC channels in pathogenesis of pancreatitis
10.3969/j.issn.1000-4718.2024.00.025
- VernacularTitle:CRAC通道在胰腺炎发病机制中作用的研究进展
- Author:
Shuang PENG
1
;
Zelin SUN
;
Die LIAO
;
Xiaolin YANG
;
Lu KE
Author Information
1. 广州体育学院运动与健康学院,广东 广州 510500;广州体育学院国家体育总局运动技战术诊断与机能评定重点实验室,广东 广州 510500;暨南大学基础医学与公共卫生学院病理生理学系,国家中医药管理局病理生理实验室,广东 广州 510632
- Publication Type:Journal Article
- Keywords:
calcium release-activated calcium channels;
calcium signaling;
calcium overload;
acute pancre-atitis;
chronic pancreatitis
- From:
Chinese Journal of Pathophysiology
2024;40(12):2351-2358,2366
- CountryChina
- Language:Chinese
-
Abstract:
Calcium release-activated calcium(CRAC)channels are non-selective calcium channels that are widely expressed in non-excitable cells.The opening of CRAC channels serves as a primary mechanism for calcium entry in various pancreatic and immune cells.Consequently,CRAC channels are crucial for maintaining Ca2+homeostasis and supporting numerous physiological functions of the exocrine pancreas.Numerous studies have identified CRAC channels as playing a pivotal role in many pathophysiological events that ultimately contribute to both acute and chronic pancreati-tis.In this review,we aim to highlight recent discoveries regarding the involvement of CRAC channels in the pathogenesis of acute and chronic pancreatitis,while also discussing current applications and future directions for CRAC channel-based drug development.
