Pathogenic and genetic characteristics of Yersinia enterocolitica in Jiangsu Province from 2005 to 2019
10.3969/j.issn.1002-2694.2024.00.152
- VernacularTitle:2005-2019年江苏省小肠结肠耶尔森菌的病原学和遗传学特征研究
- Author:
Ming-hui FU
1
;
Yan WANG
;
Xiao-juan ZHU
;
Lu ZHOU
;
Jing-xian LIU
;
Ya-wen XU
;
Hua-fu YANG
;
Lun-biao CUI
;
Qin XU
;
Bin WU
Author Information
1. 江苏省疾病预防控制中心(江苏省预防医学科学院),南京 210009
- Publication Type:Journal Article
- Keywords:
Yersinia enterocolitica;
biological serotype;
virulence genes;
resistance;
whole genome sequencing;
multilocus sequence type
- From:
Chinese Journal of Zoonoses
2024;40(11):1024-1030,1041
- CountryChina
- Language:Chinese
-
Abstract:
This study was aimed at understanding the etiological and genetic characteristics of Yersinia enterocolica isolated in Jiangsu Province between 2005 and 2019.All 110 identified strains of Y.enterocolica were from patients with foodborne diar-rhea in Jiangsu Province,or from pigs,dogs,cattle,sheep,poultry,flies,or food.Virulence genes,biological serotypes,drug resistance,multilocus sequence typing(MLST),and core genome multilocus sequence typing(cgMLST)based on whole-genome sequencing were performed.The strains included 27 pathogenic strains(24.5％)and 83 non-pathogenic strains(75.5％).Non-pathogenic strains accounted for a high proportion,particularly among strains from patients(15/16,93.8％).The biological serotypes of pathogenic strains were mainly type 3/O∶3(26/27,96.3％).Non-pathogenic strains included 1A/O∶8 type(23/83,27.7％),1 A/O∶5 type(14/83,16.9％),and the other four biological serotypes(excluding unknown se-rotypes).Pathogenic strains were dominated by type 3/O∶3(26/27,96.3％),and more than 80％of these strains were sensi-tive to 19 antibiotic types.Whole-genome sequencing indicated that the pathogenic strains were all ST135 type,whereas the non-pathogenic strains were more diverse and scattered.HierCC clustering analysis grouped all strains into three clus-ters:pathogenic strains were in one cluster,and strains from patients were found in all three clusters.In conclusion,the Y.enterocolica strains from patients were primarily non-patho-genic.Non-pathogenic strains showed richer epigenetic and ge-netic diversity than pathogenic strains.The monitoring of these strains should be strengthened to decrease the risk of human infection.
