Related factors analysis of neuropsychiatric co-morbidities in children with epilepsy
10.3760/cma.j.issn.1673-4912.2025.03.004
- VernacularTitle:癫痫患儿神经精神共患病的相关因素分析
- Author:
Xinying ZHANG
1
;
Meng SUN
1
;
Jiangya WANG
1
;
Yaying CHENG
1
Author Information
1. 河北省人民医院儿科，石家庄 050051
- Publication Type:Journal Article
- Keywords:
Epilepsy;
Intellectual developmental disorder;
Neuropsychiatric comorbidities;
Children;
Associated factors
- From:
Chinese Pediatric Emergency Medicine
2025;32(3):181-185
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the intellectual development,mental behavior and social adaptability of children with epilepsy，and to analyze the related factors affecting the intellectual development，mental behavior and social adaptability.Methods:A total of 290 children with epilepsy diagnosed and treated in the department of pediatrics at Hebei General Hospital from January 2017 to January 2022 were randomly selected as study subjects.The Gesell Developmental Negotiation Scale or Wechsler Intelligence Scale was used to comprehensively assess their intellectual development,and they were divided into the retarded intellectual development group( n=121) and the control group( n=169) with normal intellectual development,according to the presence or absence of retarded intellectual development. Results:The differences in disease duration,frequency of epilepsy,status epilepticus，and numbers of antiepileptic drugs between the two groups were statistically significant(all P<0.05),while there were no statistically significant differences in age,gender,age at onset,seizure form,interictal epileptiform discharges,history of febrile convulsions,and the time from onset to initial visit（ P>0.05）.Multifactorial Logistic regression analysis showed that high seizure frequency( OR=0.713， P<0.05),long duration of illness( OR=0.893， P<0.05),and high number of antiepileptic drugs( OR=0.630， P<0.05) were the high-risk factors for the occurrence of retarded intellectual development in children with epilepsy. Conclusion:High frequency of seizures,long duration of the disease and high number of antiepileptic drugs are risk factors for retarded intellectual development in children with epilepsy,and should be prevented and controlled early.Avoidance of multidrug combinations is one of the currently modifiable factors.
