Black hairy tongue due to linezolid
10.3760/cma.j.cn114015-20190121-00066
- VernacularTitle:利奈唑胺致黑毛舌
- Author:
Jianghua SHEN
1
;
Yahui YU
;
Haoxin SONG
;
Yanqi CHU
Author Information
1. 首都医科大学宣武医院药剂科/国家老年疾病临床医学研究中心，北京 100053
- Publication Type:Journal Article
- Keywords:
Linezolid;
Tongue diseases;
Tongue, hairy
- From:
Adverse Drug Reactions Journal
2020;22(7):432-434
- CountryChina
- Language:Chinese
-
Abstract:
An 83-year-old male patient received IV infusions of linezolid 600 mg once per 12 hours and imipenem and cilastatin sodium 1 g once per 8 hours for incisional wound infection after cervical spinal fusion. Three days later, imipenem and cilastatin sodium was stopped according to the drug sensitive test result and linezolid was continued. Two weeks after the use of linezolid, the patient developed dry mouth, and abnormal sensation of tongue; and 18 days later, he developed black tongue coating in the center of the tongue, which could not relieved after drinking a lot of water. After that, the tooth root blackened and the denture pigmented gradually. It was considered as black hairy tongue, which might be associated with linezolid. Linezolid was stopped and compound chlorhexidine gargle was given for gargling. Twelve days later, the patient′s tongue coating returned to normal, the symptoms of dry mouth and thirst disappeared, and the color of tooth root became lighter.
