Predictive value of inflammatory factors and renal function indicators for diabetic retinopathy in patients with type 2 diabetes mellitus and their risk factors
10.3760/cma.j.cn431274-20240927-01489
- VernacularTitle:炎症因子、肾功能指标对T2DM患者并发糖尿病视网膜病变的预测价值及其危险因素
- Author:
Jiaming ZHANG
1
;
Yingxin CHEN
1
;
Tongzhu FENG
1
Author Information
1. 中国人民解放军北部战区总医院眼科，沈阳 110000
- Publication Type:Journal Article
- Keywords:
Diabetes mellitus, type 2;
Diabetic retinopathy;
Inflammatory factors;
Kidney function tests
- From:
Journal of Chinese Physician
2025;27(9):1372-1375
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the predictive value of inflammatory factors and renal function indicators for diabetic retinopathy (DR) in patients with type 2 diabetes mellitus (T2DM) and their risk factors.Methods:A total of 106 T2DM patients admitted to the General Hospital of PLA Northern Theater Command from March 2022 to February 2024 were prospectively selected. They were divided into the DR group (31 cases) and non-DR group (75 cases) according to the presence or absence of DR. Binary logistic regression analysis was used to screen the influencing factors of DR in T2DM patients, and receiver operating characteristic (ROC) curve was used to analyze the predictive value of inflammatory factors and renal function indicators for DR in T2DM patients.Results:Univariate analysis showed that T2DM duration, smoking, hypertension, blood urea, serum creatinine, serum uric acid, interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), and C-reactive protein (CRP) were associated with DR in T2DM patients (all P<0.05). Multivariate logistic regression analysis showed that TNF-α, serum creatinine, serum uric acid, and T2DM duration were independent risk factors for DR in T2DM patients (all P<0.05), which could increase the risk by 1.724 times, 1.038 times, 1.026 times, and 4.904 times, respectively. ROC curve analysis showed that the areas under the curve (AUC) of TNF-α, serum creatinine, and serum uric acid for predicting DR in T2DM patients were 0.906, 0.842, and 0.809, respectively. Conclusions:TNF-α, serum creatinine, serum uric acid, and T2DM duration are independent risk factors for DR in T2DM patients. TNF-α, serum creatinine, and serum uric acid have good predictive value for DR in T2DM patients, and can be used as clinical predictive indicators to provide references for early identification of high-risk patients and formulation of DR prevention and treatment strategies.
