Predictive value of platelet-to-albumin ratio for organ failure in patients with acute pancreatitis
10.3760/cma.j.cn115455-20241018-00891
- VernacularTitle:血小板与白蛋白比值预测急性胰腺炎患者器官衰竭的应用价值研究
- Author:
Yan LI
1
;
Jingjing XU
1
;
Yuqin ZHANG
1
;
Hongjin CHANG
1
Author Information
1. 济宁医学院附属医院输血科，济宁 272000
- Publication Type:Journal Article
- Keywords:
Pancreatitis;
Forecasting;
Platelet-to-albumin ratio;
Organ failure
- From:
Chinese Journal of Postgraduates of Medicine
2025;48(11):1025-1028
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the predictive value of platelet-to-albumin ratio (PAR) for organ failure in patients with acute pancreatitis (AP).Methods:The clinical data of 128 patients with AP from January 2021 to January 2024 in Affiliated Hospital of Jining Medical College were retrospectively analyzed. Among them, 68 patients developed organ failure (failure group), and 60 patients did not develop organ failure (non-failure group). The inflammatory indexes on admission were compared between the two groups. The severity of illness was evaluated by acute physiology and chronic health evaluation Ⅱ (APACHE Ⅱ) and sequential organ failure assessment (SOFA). Pearson method was employed for correlation analysis. The receiver operating characteristic (ROC) curve was utilized to analyze the efficacy of PAR in predicting organ failure in patients with AP.Results:The APACHE Ⅱ, SOFA, white blood cell, platelet, red blood cell distribution width, C-reactive protein, fasting blood glucose, blood urea nitrogen, interleukin 6 (IL-6) and PAR in failure group were significantly higher than those in non-failure group: (25.91 ± 1.46) scores vs. (20.98 ± 1.46) scores, (7.03 ± 0.17) scores vs. (5.51 ± 0.33) scores, (11.22 ± 1.77) × 10 9/L vs. (9.32 ± 1.81) × 10 9/L, (200.12 ± 24.11) × 10 9/L vs. (173.18 ± 17.19) × 10 9/L, 0.134 ± 0.007 vs. 0.112 ± 0.007, (64.12 ± 7.38) mg/L vs. (46.93 ± 9.07) mg/L,(7.23 ± 1.09) mmol/L vs. (6.56 ± 0.87) mmol/L, (6.46 ± 1.17) mmol/L vs. (3.91 ± 0.39) mmol/L, (207.32 ± 74.29) ng/L vs. (109.27 ± 33.55) ng/L and 5.79 ± 0.98 vs. 4.30 ± 0.79, the serum calcium and albumin were significantly lower than those in non-failure group: (1.58 ± 0.09) mmol/L vs. (2.19 ± 0.32) mmol/L and (35.04 ± 4.05) g/L vs. (41.10 ± 5.79) g/L, and there were statistical differences ( P<0.01). Pearson correlation analysis result showed that PAR was positively correlated with APACHE Ⅱ, SOFA, white blood cell, platelet, red blood cell distribution width, C-reactive protein, fasting blood glucose, blood urea nitrogen and IL-6 ( r = 0.559, 0.623, 0.237, 0.782, 0.511, 0.392, 0.287, 0.555 and 0.505; P<0.01), and negatively correlated with serum calcium and albumin ( r = - 0.526 and - 0.820, P<0.01). ROC curve analysis result showed that the area under the curve of PAR for predicting organ failure in patients with AP was 0.875 (95% CI 0.818 to 0.933), with an optimal cutoff value of 4.56, sensitivity of 91.2%, and specificity of 66.7%. Conclusions:PAR can effectively predict the occurrence of organ failure in AP patients with high sensitivity, providing certain guiding significance for clinical treatment.
