Changes of serum interferon-inducible protein 10 and hypersensitive C-reactive protein in children with recurrent respiratory tract infection and their correlation with prognosis
10.3760/cma.j.cn115455-20241010-00849
- VernacularTitle:反复呼吸道感染患儿血清干扰素诱生蛋白10、超敏C-反应蛋白变化及其与预后的相关性
- Author:
Jing LIU
1
;
Qiuyan DU
Author Information
1. 宝鸡市妇幼保健院儿童感染科，宝鸡 721000
- Publication Type:Journal Article
- Keywords:
Respiratory tract infections;
Interferon-inducible protein-10;
Hypersensitivity C-reactive protein;
Prognosis;
Child
- From:
Chinese Journal of Postgraduates of Medicine
2025;48(8):729-733
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the changes of serum interferon-inducible protein 10(IP-10) and hypersensitive C-reactive protein(hs-CRP) in children with recurrent respiratory tract infection(RRTI) and their correlation with prognosis.Methods:A total of 62 children with RRTI(RRTI group) and 58 healthy children (healthy control group) who underwent physical examination during the same period from October 2022 to December 2023 in Baoji Maternal and Child Health Hospital were retrospectively selected as the study objects. The levels of serum IP-10 and hs-CRP were compared between the two groups. Univariate analysis and multivariate Logistic regression analysis were used to screen the risk factors for poor prognosis in children with RRTI, and receiver operating characteristic (ROC) curve was used to analyze the predictive value of serum hs-CRP and IP-10 levels for poor prognosis in children with.Results:The serum levels of hs-CRP and IP-10 in the RRTI group were higher than those in the healthy control group: (110.23 ± 21.56) ng/L vs. (29.56 ± 4.53) ng/L, (3.63 ± 0.64) mg/L vs. (2.85 ± 0.52) mg/L, there were statistical differences ( P<0.05). The results of univariate analysis showed that exposure to second-hand smoke, household pets, history of asthma and elevated levels of procalcitonin, serum amyloid, IP-10 and hs-CRP were risk factors for poor prognosis in children with RRTI ( P<0.05). Logistic regression analysis showed that exposure to second-hand smoke and increased levels of serum IP-10 and hs-CRP were independent risk factors for poor prognosis in RRTI children ( P<0.05). ROC curve analysis showed that the area under the curve of serum IP-10 and hs-CRP combined to predict poor prognosis of RRTI children was 0.866, which was higher than any single index. Conclusions:The serum levels of IP-10 and hs-CRP are obviously elevated in children with RRTI and those with poor prognosis. The combined detection of IP-10 and hs-CRP has predictive value for poor prognosis in children with RRTI.
