Prognostic Value of Adrenocorticotropic Hormone in Patients with Newly Diagnosed Acute Myeloid Leukemia
10.11969/j.issn.1673-548X.2024.11.010
- VernacularTitle:促肾上腺皮质激素在初诊急性髓系白血病患者中的预后价值分析
- Author:
Linlin DING
1
;
Miao-miao ZHAO
1
;
Wenjie LIU
1
Author Information
1. 210029 南京医科大学第一附属医院血液科
- Publication Type:Journal Article
- Keywords:
Adrenocorticotropic hormone;
Acute myeloid leukemia;
Risk factors;
Nomogram model
- From:
Journal of Medical Research
2024;53(11):46-50
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the clinical characteristics and prognostic significance of adrenocorticotropic hormone(ACTH)level in patients with acute myeloid leukemia(AML).Methods A total of 235 AML patients were enrolled from January 2015 to October 2021.The survival curves between ACTH groups were drawn by Kaplan-Meier.The risk factors of overall survival(OS)were analyzed by COX regression analysis.The prognostic model was constructed by R software and verified by calibration curve.Results Among 235 AML patients,the ACTH level of 40 patients were lower than 7.2pg/ml.Kaplan-Meier survival curve analysis indicated that the survival time of patients with low ACTH was significantly shortened.Univariate analysis showed that age,prognosis classification of European Leu-kemia Net(ELN),Eastern Cooperative Oncology Group(ECOG)score,and ACTH were correlated with poor survival in AML patients(P＜0.05).Multivariate COX regression analysis showed that age,prognosis classification of ELN,ECOG score,and ACTH level were the independent factors for patient survival(P＜0.05).A nomogram and calibration curves for predicting overall survival were construc-ted using these factors,which showed that the calibration curve of the model was close to the standard curve,showing a good linear rela-tionship.Conclusion Low ACTH level is an independent prognostic factor for survival in AML patients,and a model of nomogram con-structed based on age,prognostic classification of ELN,ECOG score and ACTH level has a good predictive value.
