Application of Rabbit Carotid Atherosclerotic Plaque Neovascularization using Ultrasound Localization Microscopy
10.11969/j.issn.1673-548X.2024.11.008
- VernacularTitle:超高分辨率超声测量兔颈动脉粥样硬化斑块内新生血管的应用价值
- Author:
Junyi REN
1
;
Wen-kun BAI
1
;
Yuanyi ZHENG
1
Author Information
1. 200233 上海交通大学医学院附属第六人民医院超声科
- Publication Type:Journal Article
- Keywords:
Intraplaque neovascularization;
Ultrasound localization microscopy;
Artificial intelligence
- From:
Journal of Medical Research
2024;53(11):35-39
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation between intraplaque neovascularization(IPN)parameters using ultrasound lo-calization microscopy(ULM)and pathological results.Methods Atherosclerosis of the carotid artery in rabbit was induced using balloon catheter damage and a high-cholesterol diet.ULM technology was used to measure the IPN,and the parameters of neovascularization density,diameter,distortion and velocity were quantified,and compared with pathological results,to evaluate the reliability of ULM tech-nique in detecting and measuring the parameters of IPN.Results ULM technology can perform ultra-high resolution imaging of the IPN in rabbit carotid atherosclerotic plaques,and can accurately measured the density of IPN.The correlation with pathological diagnosis was good(r=0.915,P＜0.05).Conclusion ULM technique has a certain reliability in detecting the IPN in rabbit carotid atherosclerotic plaque.
