Research progress of tumor molecular imaging technology targeting trop2
10.3760/cma.j.cn431274-20240817-01269
- VernacularTitle:靶向Trop2的肿瘤分子影像技术研究进展
- Author:
Wenpeng HUANG
1
;
Yongshun LIU
1
;
Xinyao SUN
1
;
Yihan YANG
1
;
Lei KANG
1
Author Information
1. 北京大学第一医院核医学科，北京 100034
- Publication Type:Journal Article
- Keywords:
Trophoblast cell surface antigen 2;
Solid tumor;
Molecular imaging
- From:
Journal of Chinese Physician
2025;27(10):1589-1592
- CountryChina
- Language:Chinese
-
Abstract:
Trophoblast cell surface antigen 2 (Trop2) is a transmembrane glycoprotein. It promotes development and coordinates intracellular calcium signal transduction in healthy tissues, but is overexpressed in a variety of solid malignant tumors (such as gastrointestinal tumors, ovarian cancer, prostate cancer, and breast cancer). Moreover, it is closely associated with poor tumor prognosis and metastasis risk. As a powerful tool, molecular imaging technology can directly characterize and quantify the molecular metabolic changes after the combination of probes and targets through imaging technology at the in vivo level. It has become a key technology for Trop2 research and plays an important role in specific diagnosis, tumor staging, and therapeutic effect monitoring. A variety of Trop2-targeted molecular probes based on monoclonal antibodies, antibody-drug conjugates, and antibody fragments have been used in preclinical and clinical studies of various solid tumors. This article reviews the latest progress of Trop2-related research in the field of tumor molecular imaging technology.
